Efficacy of alpha-mangostin for antimicrobial activity against endodontopathogenic microorganisms in a multi-species bacterial-fungal biofilm model.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2021.105304
Abstract: OBJECTIVE To determine the activity of alpha-mangostin on preformed bacterial-fungal multi-species biofilms in vitro, and to ascertain the impact on metabolic activity, biofilm structure and viability. DESIGN Inhibitory concentrations (ICs) for alpha-mangostin against planktonic cultures… read more here.
Keywords: multi species; biofilm; alpha mangostin; bacterial fungal ... See more keywords
Inhibition of biofilm formation by alpha-mangostin loaded nanoparticles against Staphylococcus aureus
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2020.11.061
Abstract: This study aimed to investigate the antibiofilm activity of alpha-mangostin (AMG) loaded nanoparticles (nanoAMG) against Staphylococcus aureus, including the methicillin-resistant strain MRSA252. The results indicated that treatment with 24 μmol/L nanoAMG inhibited the formation of… read more here.
Keywords: staphylococcus aureus; biofilm formation; formation; loaded nanoparticles ... See more keywords
Alpha-Mangostin Reverses Multidrug Resistance by Attenuating the Function of the Multidrug Resistance-Linked ABCG2 Transporter.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00334
Abstract: The ATP-binding cassette (ABC) drug transporter ABCG2 can actively efflux a wide variety of chemotherapeutic agents out of cancer cells and subsequently reduce the intracellular accumulation of these drugs. Therefore, the overexpression of ABCG2 often… read more here.
Keywords: alpha mangostin; resistance; cancer cells; multidrug resistance ... See more keywords
Alpha-Mangostin-Loaded Transferrin-Conjugated Lipid-Polymer Hybrid Nanoparticles: Development and Characterization for Tumor-Targeted Delivery
Sign Up to like & getrecommendations! Published in 2022 at "The Scientific World Journal"
DOI: 10.1155/2022/9217268
Abstract: Alpha-mangostin, a natural xanthone mainly extracted from the pericarp of Garcinia mangostana, has been shown to have promising anticancer properties in many types of cancer. However, the therapeutic potential of α-mangostin has been limited so… read more here.
Keywords: alpha mangostin; lphn; transferrin conjugated; mangostin ... See more keywords
Protective effect of alpha-mangostin on thioacetamide-induced liver fibrosis in rats as revealed by morpho-functional analysis.
Sign Up to like & getrecommendations! Published in 2019 at "Histology and histopathology"
DOI: 10.14670/hh-18-052
Abstract: Liver fibrosis is an excessive accumulation of scar tissue resulting from inflammation and cell death. Thioacetamide (TAA) is a well-known hepatotoxin that induces liver fibrosis. A marker of injured hepatocytes is transforming growth factor-beta 1… read more here.
Keywords: effect; alpha mangostin; liver fibrosis; mangostin ... See more keywords
Effects of alpha-mangostin on memory senescence induced by high glucose in human umbilical vein endothelial cells
Sign Up to like & getrecommendations! Published in 2020 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2020.40651.9612
Abstract: Objective(s): Hyperglycemia induces cellular senescence in various body cells, such as vascular endothelial cells. Since the vessels are highly distributed in the body and nourish all tissues, vascular damages cause diabetes complications such as kidney… read more here.
Keywords: memory senescence; senescence; high glucose; alpha mangostin ... See more keywords
Effect of alpha-mangostin on olanzapine-induced metabolic disorders in rats
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.58734.13047
Abstract: Objective(s): As olanzapine has side effects such as weight gain and metabolic disorders, and alpha-mangostin has been shown to control metabolic disorders, the effects of alpha-mangostin on metabolic disorders induced by olanzapine were investigated in… read more here.
Keywords: day; liver tissue; ampk; alpha mangostin ... See more keywords
In Vitro and In Vivo Bactericidal and Antibiofilm Efficacy of Alpha Mangostin Against Staphylococcus aureus Persister Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.898794
Abstract: The formation of persister cells is associated with recalcitrance and infections. In this study, we examined the antimicrobial property of alpha mangostin, a natural xanthone molecule, against methicillin-resistant Staphylococcus aureus (MRSA) persisters and biofilm. The… read more here.
Keywords: staphylococcus aureus; alpha mangostin; persister cells; mangostin ... See more keywords
Modulatory Effects of Alpha-Mangostin Mediated by SIRT1/3-FOXO3a Pathway in Oxidative Stress-Induced Neuronal Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2021.714463
Abstract: Background alpha-Mangostin, a polyphenolic xanthone, is primarily found in the pericarp of mangosteen throughout Southeast Asia and is considered as the “Queen of Fruit” in Thailand. Nonetheless, it is not clarified how alpha-mangostin protects neuronal… read more here.
Keywords: oxidative stress; stress induced; alpha mangostin; neuronal cells ... See more keywords
Alpha-Mangostin Improves Insulin Secretion and Protects INS-1 Cells from Streptozotocin-Induced Damage
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19051484
Abstract: Alpha (α)-mangostin, a yellow crystalline powder with a xanthone core structure, is isolated from mangosteen (Garcinia mangostana), which is a tropical fruit of great nutritional value. The aim of the present study was to investigate… read more here.
Keywords: insulin secretion; alpha mangostin; mangostin; ins cells ... See more keywords
Hyaluronic Acid-Coated Chitosan Nanoparticles as an Active Targeted Carrier of Alpha Mangostin for Breast Cancer Cells
Sign Up to like & getrecommendations! Published in 2023 at "Polymers"
DOI: 10.3390/polym15041025
Abstract: Alpha mangostin (AM) has potential anticancer properties for breast cancer. This study aims to assess the potential of chitosan nanoparticles coated with hyaluronic acid for the targeted delivery of AM (AM-CS/HA) against MCF-7 breast cancer… read more here.
Keywords: cancer cells; chitosan nanoparticles; breast cancer; alpha mangostin ... See more keywords