Effectively enhancing cytotoxic and apoptotic effects of alpha‐momorcharin by integrating a heparin‐binding peptide
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1553
Abstract: Alpha‐momorcharin (α‐MMC), a type I ribosome‐inactivating protein, has attracted a great deal of attention because of its antitumor activity. However, the cytotoxicity of α‐MMC is limited due to insufficient cellular internalization in cancer cells. To… read more here.
Keywords: alpha momorcharin; heparin binding; mmc hbp; hbp ... See more keywords
Alpha-momorcharin regulates cytokine expression and induces apoptosis in monocytes
Sign Up to like & getrecommendations! Published in 2019 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2019.1610430
Abstract: Abstract Background and aim: Alpha-momorcharin (α-MMC) is a type I ribosome-inactivating protein (RIP) that is purified from Momordica charantia. Despite its strong antitumor activities, α-MMC exerts the undesirable immunotoxicity effects of hypersensitivity or immunosuppression. Since… read more here.
Keywords: alpha momorcharin; cell line; cytokine expression; expression ... See more keywords