Visualization of the three-dimensional structure of the human centromere in mitotic chromosomes by super-resolution microscopy.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-08-0332
Abstract: The human centromere comprises large arrays of repetitive alpha-satellite DNA at the primary constriction of mitotic chromosomes. In addition, centromeres are epigenetically specified by the centromere-specific histone H3 variant CENP-A that supports kinetochore assembly to… read more here.
Keywords: microscopy; mitotic chromosomes; human centromere; satellite dna ... See more keywords
Alpha satellite insertion close to an ancestral centromeric region.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology and evolution"
DOI: 10.1093/molbev/msab244
Abstract: Human centromeres are mainly composed of alpha satellite DNA hierarchically organized as higher-order repeats (HORs). Alpha satellite dynamics is shown by sequence homogenization in centromeric arrays and by its transfer to other centromeric locations, for… read more here.
Keywords: satellite insertion; alpha satellite; close ancestral; insertion ... See more keywords
Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13020383
Abstract: The aberrant overexpression of alpha satellite DNA is characteristic of many human cancers including prostate cancer; however, it is not known whether the change in the alpha satellite RNA amount occurs in the peripheral tissues… read more here.
Keywords: prostate cancer; blood; satellite rna; cancer ... See more keywords