Phosphorylated alpha‐synuclein in Iba1‐positive macrophages in the skin of patients with Parkinson's disease
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DOI: 10.1002/acn3.51610
Abstract: Increasing evidence suggests that alpha‐synuclein (αSyn) accumulation in cholinergic and adrenergic fibers in the skin is a useful biomarker to diagnose idiopathic Parkinson's disease (IPD). It has been widely reported that phosphorylated αSyn (p‐αSyn) deposits… read more here.
Keywords: iba1 positive; parkinson disease; alpha synuclein; synuclein iba1 ... See more keywords
Cervical skin denervation associates with alpha‐synuclein aggregates in Parkinson disease
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DOI: 10.1002/acn3.669
Abstract: Autonomic nervous system is involved at the onset of Parkinson disease (PD), and alpha‐synuclein (α‐Syn) and its phosphorylated form (p‐αSyn) have been detected in dermal autonomic nerve fibers of PD. We assessed disease specific conformation… read more here.
Keywords: alpha synuclein; skin denervation; disease; parkinson disease ... See more keywords
Plasma alpha‐synuclein detected by single molecule array is increased in PD
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DOI: 10.1002/acn3.729
Abstract: We utilized ultrasensitive single molecule technology to measure plasma alpha‐synuclein in 221 subjects (51 controls, 170 PD). Plasma alpha‐synuclein levels were significantly higher in PD than controls (15506.3 vs. 13057.0 pg/mL, P = 0.037), adjusting… read more here.
Keywords: plasma alpha; alpha synuclein; single molecule; alpha ... See more keywords
Controlled Activation of TRPV1 Channels on Microglia to Boost Their Autophagy for Clearance of Alpha‐Synuclein and Enhance Therapy of Parkinson's Disease
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DOI: 10.1002/adma.202108435
Abstract: Parkinson's disease (PD) is characterized with accumulation of Lewy bodies with a major component of fibrillar alpha‐synuclein (α‐syn). Herein, boosting PD therapeutic efficacy by enhancing the autophagy of microglia to phagocytose and degrade α‐syn via… read more here.
Keywords: parkinson disease; trpv1 channels; syn; alpha synuclein ... See more keywords
Modeling Parkinson's disease‐related symptoms in alpha‐synuclein overexpressing mice
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DOI: 10.1002/brb3.2628
Abstract: Intracellular deposition of alpha‐synuclein (α‐syn) as Lewy bodies and Lewy neurites is a central event in the pathogenesis of Parkinson's disease (PD) and other α‐synucleinopathies. Transgenic mouse models overexpressing human α‐syn, are useful research tools… read more here.
Keywords: related symptoms; disease related; modeling parkinson; parkinson disease ... See more keywords
Separation and determination of alpha‐synuclein monomeric and oligomeric species using two electrophoretic approaches
Sign Up to like & getrecommendations! Published in 2018 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201800224
Abstract: Parkinson's disease (PD) is a frequent degenerative disorder that is diagnosed based on clinical symptoms. When the first symptoms appear, more than 70% of the dopaminergic cells are already lost. Therefore, it is of utmost… read more here.
Keywords: oligomeric species; separation determination; monomeric oligomeric; synuclein monomeric ... See more keywords
Autonomic dysfunction in genetic forms of synucleinopathies
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DOI: 10.1002/mds.27343
Abstract: The discovery of genetic links between alpha‐synuclein and PD has opened unprecedented opportunities for research into a new group of diseases, now collectively known as synucleinopathies. Autonomic dysfunction, including cardiac sympathetic denervation, has been reported… read more here.
Keywords: lewy bodies; dysfunction genetic; dysfunction; forms synucleinopathies ... See more keywords
Reply To: Detection of Alpha‐Synuclein in Saliva: The Importance of Preanalytical Assessment
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DOI: 10.1002/mds.27424
Abstract: We thank Dr. Vivacqua and colleagues for their interest in our article and appreciation of the importance of easily accessible, noninvasive biomarkers such as saliva measures and the potential value of comparing different biological fluids… read more here.
Keywords: synuclein saliva; reply detection; detection alpha; saliva importance ... See more keywords
Alpha‐Synuclein is Involved in DYT1 Dystonia Striatal Synaptic Dysfunction
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DOI: 10.1002/mds.29024
Abstract: The neuronal protein alpha‐synuclein (α‐Syn) is crucially involved in Parkinson's disease pathophysiology. Intriguingly, torsinA (TA), the protein causative of DYT1 dystonia, has been found to accumulate in Lewy bodies and to interact with α‐Syn. Both… read more here.
Keywords: dystonia striatal; involved dyt1; dyt1 dystonia; synuclein involved ... See more keywords
Interactions between the Intrinsically Disordered Proteins β‐Synuclein and α‐Synuclein
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DOI: 10.1002/pmic.201800109
Abstract: Several intrinsically disordered proteins have been implicated in the process of amyloid fibril formation in neurodegenerative disease, and developing approaches to inhibit the aggregation of these intrinsically disordered proteins is critical for establishing effective therapies… read more here.
Keywords: beta synuclein; synuclein; alpha synuclein; disordered proteins ... See more keywords
Probing Alpha-Synuclein Conformations by Electron Paramagnetic Resonance (EPR) Spectroscopy.
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DOI: 10.1007/978-1-4939-9124-2_19
Abstract: Electron paramagnetic resonance (EPR) spectroscopy in combination with site-directed spin labeling is ideally suited to study structure, dynamics, and interactions of intrinsically disordered proteins as alpha-synuclein.Here we describe all steps required for a corresponding study:… read more here.
Keywords: paramagnetic resonance; electron paramagnetic; epr spectroscopy; spectroscopy ... See more keywords