Targeted Alpha Therapy, an Emerging Class of Cancer Agents: A Review
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2018.4044
Abstract: Importance Targeted alpha therapy attempts to deliver systemic radiation selectively to cancer cells while minimizing systemic toxic effects and may lead to additional treatment options for many cancer types. Observations Theoretically, the high-energy emission of… read more here.
Keywords: cancer; treatment; targeted alpha; alpha therapy ... See more keywords
Application of a new spectral deconvolution method for in vitro dosimetry in assessment of targeted alpha therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Medical physics"
DOI: 10.1002/mp.16279
Abstract: BACKGROUND The improvement of in vitro assessment of targeted alpha therapy (reproducibility, comparability of experiments…) requires precise evaluation of the dose delivered to the cells. To answer this need, a previous study proposed an innovative… read more here.
Keywords: alpha therapy; deconvolution; targeted alpha; deconvolution method ... See more keywords
Development and dosimetry of 203Pb/212Pb-labelled PSMA ligands: bringing “the lead” into PSMA-targeted alpha therapy?
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-018-4220-z
Abstract: PurposeThe aims of this study were to develop a prostate-specific membrane antigen (PSMA) ligand for labelling with different radioisotopes of lead and to obtain an approximation of the dosimetry of a simulated 212Pb-based alpha therapy… read more here.
Keywords: ca012; alpha therapy; 203pb 212pb; dosimetry ... See more keywords
Alpha-Emitters and Targeted Alpha Therapy in Oncology: from Basic Science to Clinical Investigations
Sign Up to like & getrecommendations! Published in 2018 at "Targeted Oncology"
DOI: 10.1007/s11523-018-0550-9
Abstract: Alpha-emitters are radionuclides that decay through the emission of high linear energy transfer α-particles and possess favorable pharmacologic profiles for cancer treatment. When coupled with monoclonal antibodies, peptides, small molecules, or nanoparticles, the excellent cytotoxic… read more here.
Keywords: emitters targeted; alpha therapy; targeted alpha; therapy ... See more keywords
Manual on the proper use of sodium astatide ([211At]NaAt) injections in clinical trials for targeted alpha therapy (1st edition)
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Nuclear Medicine"
DOI: 10.1007/s12149-021-01619-2
Abstract: We present the guideline for use of [211At] sodium astatide (NaAt) for targeted alpha therapy in clinical trials on the basis of radiation safety issues in Japan. This guideline was prepared by a study supported… read more here.
Keywords: medicine; alpha therapy; 211at naat; clinical trials ... See more keywords
Elucidating the coordination chemistry of the radium ion for targeted alpha therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03156f
Abstract: The coordination chemistry of Ra2+ is poorly defined, hampering efforts to design effective chelators for 223Ra-based targeted alpha therapy. Here, we report the complexation thermodynamics of Ra2+ with the biomedically-relevant chelators DOTA and macropa. Our… read more here.
Keywords: chemistry; coordination chemistry; alpha therapy; targeted alpha ... See more keywords
Ion-Exchange Kinetics of Alpha-Zirconium Phosphate Nanoplatelets for Application in Targeted Alpha Therapy
Sign Up to like & getrecommendations! Published in 2020 at "Solvent Extraction and Ion Exchange"
DOI: 10.1080/07366299.2020.1780699
Abstract: ABSTRACT The loading and kinetics of uptake for the inorganic ion-exchange material, α-zirconium phosphate, Zr(HPO4)2•H2O, were investigated with ions relevant to targeted alpha therapy including natural Cs+ (as a surrogate for 221Fr), natural Bi3+ (as… read more here.
Keywords: alpha therapy; ion exchange; zirconium phosphate; targeted alpha ... See more keywords
Revisiting the Radiobiology of Targeted Alpha Therapy
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.692436
Abstract: Targeted alpha therapy (TAT) using alpha particle-emitting radionuclides is in the spotlight after the approval of 223RaCl2 for patients with metastatic castration-resistant prostate cancer and the development of several alpha emitter-based radiopharmaceuticals. It is acknowledged… read more here.
Keywords: alpha therapy; radiobiology targeted; radiobiology; targeted alpha ... See more keywords
Targeted alpha therapy for glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.1085245
Abstract: According to the 2021 World Health Organization Classification of Tumors of the Central Nervous System, glioblastoma (GB) is a primary brain tumor and presents with the worst prognosis. Due to its infiltrating characteristic, molecular heterogeneity,… read more here.
Keywords: alpha therapy; targeted alpha; therapy glioblastoma; treatment ... See more keywords
Intraperitoneal alpha therapy with 224Ra-labeled microparticles combined with chemotherapy in an ovarian cancer mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.995325
Abstract: A novel alpha-therapy consisting of 224Ra-labeled calcium carbonate microparticles (224Ra-CaCO3-MP) has been designed to treat micrometastatic peritoneal disease via intraperitoneal (IP) administration. This preclinical study aimed to evaluate its efficacy and tolerability when given as… read more here.
Keywords: 224ra labeled; ovarian cancer; 224ra caco3; alpha therapy ... See more keywords
Towards Targeted Alpha Therapy with Actinium-225: Chelators for Mild Condition Radiolabeling and Targeting PSMA—A Proof of Concept Study
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13081974
Abstract: Simple Summary In nuclear medicine, therapeutic methods are used increasingly, in which tumors are destroyed by ionizing radiation that cannot or can only be treated insufficiently by other methods like surgery or chemotherapy. Targeted alpha… read more here.
Keywords: alpha therapy; chemistry; targeted alpha; cell ... See more keywords