Effect of 2 Emulsion-Based Adjuvants on the Structure and Thermal Stability of Staphylococcus aureus Alpha-Toxin.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.05.019
Abstract: The effects of 2 squalene-based emulsion adjuvant systems (MedImmune emulsion 0 [ME.0] and Stable Emulsion [SE]) on the structure and stability of the recombinant protein antigen alpha-toxin (AT), a potential vaccine candidate for Staphylococcus aureus… read more here.
Keywords: staphylococcus aureus; alpha toxin; spectroscopy; stability ... See more keywords
Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma
Sign Up to like & getrecommendations! Published in 2020 at "Oncoimmunology"
DOI: 10.1080/2162402x.2020.1751561
Abstract: ABSTRACT Staphylococcus aureus and its toxins have been linked to disease progression and mortality in advanced stages of cutaneous T-cell lymphoma (CTCL). CD8+ T cells play a crucial role in anti-cancer responses and high CD8+… read more here.
Keywords: cd8 cell; alpha toxin; cd8; staphylococcus aureus ... See more keywords
Changes in volatile organic compounds provoked by lipopolysaccharide- or alpha toxin-induced inflammation in ventilated rats.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of breath research"
DOI: 10.1088/1752-7163/abb449
Abstract: Inflammation may alter volatile organic compounds (VOCs) in exhaled breath. We therefore used ion mobility spectrometry (IMS) to evaluate exhaled breath components in two non-infectious inflammatory models. Fifty male Sprague Dawley rats were anesthetized and… read more here.
Keywords: high dose; alpha toxin; inflammation; toxin ... See more keywords
Abstract 2055: Staphylococcus aureus alpha toxin activates Notch in endothelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2055
Abstract: Background. Staphylococcus aureus infection is one of the leading causes of morbidity in hospitalized patients in the United States. The secreted agent hemolysin alpha toxin (Hla) requires the receptor A Disintegrin And Metalloproteinase domain-containing protein… read more here.
Keywords: staphylococcus aureus; alpha toxin; hla; endothelial cells ... See more keywords
Immunogenicity of a newly developed vaccine against Clostridium perfringens alpha-toxin in rabbits and cattle
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary World"
DOI: 10.14202/vetworld.2022.1617-1623
Abstract: Background and Aim: Clostridium perfringens type A is an anaerobic bacterium that produces four major toxins (alpha, beta, epsilon, and iota) that cause various diseases. Most of the important C. perfringens-associated diseases of farm animals… read more here.
Keywords: rabbits cattle; perfringens alpha; alpha toxin; clostridium perfringens ... See more keywords
Anti-Alpha-Toxin Antibody Responses and Clinical Outcomes of Staphylococcus aureus Bacteremia
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DOI: 10.3346/jkms.2023.38.e129
Abstract: Background Alpha-toxin (AT), a major virulence factor of Staphylococcus aureus, is an important immunotherapeutic target to prevent or treat invasive S. aureus infections. Previous studies have suggested that anti-AT antibodies (Abs) may have a protective… read more here.
Keywords: clinical outcomes; bacteremia; alpha toxin; staphylococcus aureus ... See more keywords
Staphylococcus aureus Alpha-Toxin Limits Type 1 While Fostering Type 3 Immune Responses
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DOI: 10.3389/fimmu.2020.01579
Abstract: Staphylococcus aureus can cause life-threatening diseases, and hospital- as well as community-associated antibiotic-resistant strains are an emerging global public health problem. Therefore, prophylactic vaccines or immune-based therapies are considered as alternative treatment opportunities. To develop… read more here.
Keywords: immune; staphylococcus aureus; alpha toxin; toxin ... See more keywords
Clostridiumnovyi’s Alpha-Toxin Changes Proteome and Phosphoproteome of HEp-2 Cells
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DOI: 10.3390/ijms23179939
Abstract: C. novyi type A produces the alpha-toxin (TcnA) that belongs to the large clostridial glucosylating toxins (LCGTs) and is able to modify small GTPases by N-acetylglucosamination on conserved threonine residues. In contrast, other LCGTs including… read more here.
Keywords: tcna; alpha toxin; toxin; proteome phosphoproteome ... See more keywords
Major Determinants of Airway Epithelial Cell Sensitivity to S. aureus Alpha-Toxin: Disposal of Toxin Heptamers by Extracellular Vesicle Formation and Lysosomal Degradation
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DOI: 10.3390/toxins13030173
Abstract: Alpha-toxin is a major virulence factor of Staphylococcus aureus. Monomer binding to host cell membranes results in the formation of heptameric transmembrane pores. Among human model airway epithelial cell lines, A549 cells were most sensitive… read more here.
Keywords: degradation; alpha toxin; airway epithelial; toxin ... See more keywords
A simple electroelution method for rapid protein purification: isolation and antibody production of alpha toxin from Clostridium septicum
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DOI: 10.7717/peerj.3407
Abstract: Clostridium septicum produces a number of diseases in human and farm animals which, in most of the cases, are fatal without clinical intervention. Alpha toxin is an important agent and the unique lethal virulent factor… read more here.
Keywords: clostridium septicum; alpha toxin; toxin;