Aggregation of M3 (E376D) variant of alpha1- antitrypsin
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DOI: 10.1038/s41598-020-64860-1
Abstract: Alpha1-antitrypsin (α1AT) is an abundant serine-protease inhibitor in circulation. It has an important role in neutralizing the neutrophil elastase activity. Different pathogenic point mutations like Z (E342K) -α1AT have been implicated in the development of liver… read more here.
Keywords: alpha1 antitrypsin; aggregation e376d; variant alpha1; copd ... See more keywords
0038 Genioglossus muscle (GG) activity evoked by pharmacological stimulation of alpha1-adrenoceptors in pre-hypoglossal region (PHR)
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DOI: 10.1093/sleep/zsad077.0038
Abstract: The sleep-related withdrawal of noradrenergic excitation and increased cholinergic inhibition of hypoglossal motoneurons (HM), which control the tone of the GG, the largest protruder muscle of the tongue, play a critical role in obstructive sleep… read more here.
Keywords: alpha1; alpha1 adrenoceptors; muscle; activity ... See more keywords