Oxidative stress caused by accumulation of misfolded Z-type alpha1-antitrypsin
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.237
Abstract: Accumulation of misfolded human Z-type alpha1-antitrypsin protein in the endoplasmic reticulum (ER) leads to persistent ER stress and subsequent cell death, leading to liver cirrhosis. When a Saccharomyces cerevisiae ORF-deletion library was screened for the… read more here.
Keywords: type alpha1; stress; accumulation misfolded; alpha1 antitrypsin ... See more keywords
Aggregation of M3 (E376D) variant of alpha1- antitrypsin
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DOI: 10.1038/s41598-020-64860-1
Abstract: Alpha1-antitrypsin (α1AT) is an abundant serine-protease inhibitor in circulation. It has an important role in neutralizing the neutrophil elastase activity. Different pathogenic point mutations like Z (E342K) -α1AT have been implicated in the development of liver… read more here.
Keywords: alpha1 antitrypsin; aggregation e376d; variant alpha1; copd ... See more keywords
Alpha1-antitrypsin protects lung cancer cells from staurosporine-induced apoptosis: the role of bacterial lipopolysaccharide
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-66825-w
Abstract: Elevated levels of plasma alpha1-antitrypsin (AAT) correlate with a poor prognosis of various cancers. Herein, we investigated effects of exogenous AAT on non-small lung cancer cell lines with high (H1975) and very low (H661) baseline… read more here.
Keywords: apoptosis; induced apoptosis; aat; lung cancer ... See more keywords
Liver Fibrosis and Metabolic Alterations in Adults with Alpha1 Antitrypsin Deficiency Caused by the Pi*ZZ Mutation.
Sign Up to like & getrecommendations! Published in 2019 at "Gastroenterology"
DOI: 10.1053/j.gastro.2019.05.013
Abstract: BACKGROUND Alpha1 antitrypsin deficiency (AATD) is among the most common genetic disorders. Severe AATD is caused by a homozygous mutation in the SERPINA1 gene that encodes the Glu342Lys substitution (called the Pi*Z mutation). Pi*ZZ carriers… read more here.
Keywords: fibrosis; liver fibrosis; antitrypsin deficiency; mutation ... See more keywords
Heterozygous carriage of the alpha1-antitrypsin PiZ variant increases the risk to develop liver fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Zeitschrift Fur Gastroenterologie"
DOI: 10.1055/s-0037-1612696
Abstract: Pavel Strnad1,2*, Stephan Buch3*, Karim Hamesch1,2*, Janett Fischer4, Jonas Rosendahl4,5, Renate Schmelz3, Stefan Brueckner3, Mario Brosch3, Carolin V. Heimes1, Marla Gutberlet1, David Scholten1, Hans Dieter Nischalke6, Sabina Janciauskiene7, Mattias Mandorfer8, Michael Trauner8, Michael J. Way9,10,… read more here.
Keywords: michael; alpha1 antitrypsin; heterozygous carriage; piz variant ... See more keywords
Mice inflammatory responses to inhaled aerosolized LPS: effects of various forms of human alpha1-antitrypsin.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiac004
Abstract: Rodent models of lipopolysaccharide (LPS)-induced pulmonary inflammation are used for anti-inflammatory drug testing. We aimed to characterize mice responses to aerosolized LPS alone or with intraperitoneal (i.p.) delivery of alpha1-antitrypsin (AAT). Balb/c mice were exposed… read more here.
Keywords: alpha1 antitrypsin; aerosolized lps; inflammatory; mice ... See more keywords
Alpha1‐antitrypsin binds hemin and prevents oxidative activation of human neutrophils: putative pathophysiological significance
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Leukocyte Biology"
DOI: 10.1189/jlb.3a0317-124r
Abstract: Heme is a ubiquitous compound of human tissues, and it is involved in cellular physiology and metabolism. Once released from the cell, free heme oxidizes to the ferric state (hemin). High levels of hemin can… read more here.
Keywords: antitrypsin binds; hemin prevents; alpha1 antitrypsin;
Comparison among populations with severe and intermediate alpha1-antitrypsin deficiency and chronic obstructive pulmonary disease.
Sign Up to like & getrecommendations! Published in 2023 at "Minerva medica"
DOI: 10.23736/s0026-4806.22.08266-0
Abstract: BACKGROUND Severe alpha1-antitrypsin (AAT) deficiency (AATD) is associated with a high risk of airflow obstruction and emphysema. The risk of lung disease in those with intermediate AAT deficiency is unclear. Our aims were to compare… read more here.
Keywords: alpha1 antitrypsin; deficiency; disease; quality life ... See more keywords