Impact of protein conformational diversity on AlphaFold predictions
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DOI: 10.1093/bioinformatics/btac202
Abstract: MOTIVATION After the outstanding breakthrough of AlphaFold in predicting protein 3D models, new questions appeared and remain unanswered. The ensemble nature of proteins, for example, challenges the structural prediction methods because the models should represent… read more here.
Keywords: conformational diversity; impact protein; diversity; alphafold predictions ... See more keywords
Alphafold Predictions Provide Insights into the Structural Features of the Functional Oligomers of All Members of the KCTD Family
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DOI: 10.3390/ijms232113346
Abstract: Oligomerization endows proteins with some key properties such as extra-stabilization, long-range allosteric regulation(s), and partnerships not accessible to their monomeric counterparts. How oligomerization is achieved and preserved during evolution is a subject of remarkable scientific… read more here.
Keywords: oligomers members; family; members kctd; alphafold predictions ... See more keywords