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   Articles with "alpk1" as a keyword



Investigating the role of the ALPK1 signaling pathway in the pathogenesis of diabetic retinopathy

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-17122-x

Abstract: Diabetic retinopathy (DR) is a key eye-related complication linked to diabetes. Chronic inflammation is recognized as the main pathological mechanism leading to retinal damage during the onset and progression of DR. Alpha kinase 1 (ALPK1),… read more here.

Keywords: alpk1; diabetic retinopathy; role alpk1; signaling pathway ... See more keywords

Discovery and functional analysis of a novel ALPK1 variant in ROSAH syndrome

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recommendations! Published in 2024 at "Open Biology"

DOI: 10.1098/rsob.240260

Abstract: ROSAH syndrome is an autosomal dominant autoinflammatory disorder characterised by visual disturbance caused by pathogenic variation in the protein kinase ALPK1. Only two such variants have been reported to cause ROSAH syndrome to date: 66… read more here.

Keywords: alpk1; analysis; discovery functional; adp heptose ... See more keywords

ALPK1 regulates streptozotocin‐induced nephropathy through CCL2 and CCL5 expressions

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recommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.14643

Abstract: ALPK1 is associated with chronic kidney disease, gout and type 2 diabetes mellitus. Raised renal ALPK1 level in patients with diabetes was reported. Accelerated fibrotic nephropathies were observed in hyperglycaemic mice with up‐regulated ALPK1. The… read more here.

Keywords: alpk1; ccl5; ccl5 expressions; ccl2 ccl5 ... See more keywords

ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling

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recommendations! Published in 2022 at "Journal of Dental Research"

DOI: 10.1177/00220345221100179

Abstract: Temporomandibular joint osteoarthritis (TMJOA) is a common degenerative joint disease without effective intervention strategies. Previous research implied that alpha-kinase 1 (ALPK1) is involved in the inflammatory responses of gout, a chronic arthritis. Herein, we found… read more here.

Keywords: erk1 signaling; pathology; alpk1; condylar cartilage ... See more keywords

Systematic Review of the Role of Alpha-Protein Kinase 1 in Cancer and Cancer-Related Inflammatory Diseases

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recommendations! Published in 2022 at "Cancers"

DOI: 10.3390/cancers14184390

Abstract: Simple Summary Aside from the basic phosphorylation function of alpha-kinase 1 (ALPK1), little is known about its major functions. Researchers have used various forms of biotechnology and human, animal, and cellular models to better understand… read more here.

Keywords: cancer related; kinase; cancer cancer; alpk1 ... See more keywords