Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states
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DOI: 10.1101/gr.275939.121
Abstract: Astrocytes contribute to motor neuron death in amyotrophic lateral sclerosis (ALS), but whether they adopt deleterious features consistent with inflammatory reactive states remains incompletely resolved. To identify inflammatory reactive features in ALS human induced pluripotent… read more here.
Keywords: als astrocytes; inflammatory reactive; reactive states; mouse als ... See more keywords
Autophagy-Mediated Inflammatory Cytokine Secretion in Sporadic ALS Patient iPSC-Derived Astrocytes
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DOI: 10.1155/2022/6483582
Abstract: Background Astrocytes can be involved in motor neuron toxicity in amyotrophic lateral sclerosis (ALS) induced by noncell autonomous effects, and inflammatory cytokines may play the main role in mediating this process. However, the etiology of… read more here.
Keywords: als astrocytes; control; als patient; mtor ... See more keywords