Necrosome‐positive granulovacuolar degeneration is associated with TDP‐43 pathological lesions in the hippocampus of ALS/FTLD cases
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DOI: 10.1111/nan.12668
Abstract: Granulovacuolar degeneration (GVD) in Alzheimer’s disease (AD) involves the necrosome, which is a protein complex consisting of phosphorylated receptor‐interacting protein kinase 1 (pRIPK1), pRIPK3 and phosphorylated mixed lineage kinase domain‐like protein (pMLKL). Necrosome‐positive GVD was… read more here.
Keywords: necrosome positive; gvd; positive granulovacuolar; granulovacuolar degeneration ... See more keywords
Possible concurrence of TDP‐43, tau and other proteins in amyotrophic lateral sclerosis/frontotemporal lobar degeneration
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DOI: 10.1111/neup.12428
Abstract: Transactivation response DNA‐binding protein 43 kDa (TDP‐43) has been regarded as a major component of ubiquitin‐positive/tau‐negative inclusions of motor neurons and the frontotemporal cortices in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Neurofibrillary tangles… read more here.
Keywords: tdp tau; tau; tdp; tau proteins ... See more keywords
Molecular Mechanisms Underlying TDP-43 Pathology in Cellular and Animal Models of ALS and FTLD
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DOI: 10.3390/ijms22094705
Abstract: Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerative disorders that exist on a disease spectrum due to pathological, clinical and genetic overlap. In up to 97% of ALS cases and ~50% of… read more here.
Keywords: pathology; molecular mechanisms; als ftld; animal models ... See more keywords
Molecular Dissection of TDP-43 as a Leading Cause of ALS/FTLD
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DOI: 10.3390/ijms232012508
Abstract: TAR DNA binding protein 43 (TDP-43) is a DNA/RNA binding protein involved in pivotal cellular functions, especially in RNA metabolism. Hyperphosphorylated and ubiquitinated TDP-43-positive neuronal cytoplasmic inclusions are identified in the brain and spinal cord… read more here.
Keywords: dissection tdp; leading cause; als ftld; molecular dissection ... See more keywords