Dual effects of TGF‐β inhibitor in ALS ‐ inhibit contracture and neurodegeneration
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.16102
Abstract: As persistent elevation of transforming growth factor‐β (TGF‐β) promotes fibrosis of muscles and joints and accelerates disease progression in amyotrophic lateral sclerosis (ALS), we investigated whether inhibition of TGF‐β would be effective against both exacerbations.… read more here.
Keywords: tgf; dual effects; als mice; tgf inhibitor ... See more keywords
Assessing the therapeutic impact of resveratrol in ALS SOD1-G93A mice with electrical impedance myography
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.1059743
Abstract: To aid in the identification of new treatments for amyotrophic lateral sclerosis (ALS), convenient biomarkers are needed to effectively and uniformly measure drug efficacy. To this end, we assessed the effects of the nutraceutical resveratrol… read more here.
Keywords: electrical impedance; sod1 g93a; cmap amplitude; impedance myography ... See more keywords
Swim Training Ameliorates Hyperlocomotion of ALS Mice and Increases Glutathione Peroxidase Activity in the Spinal Cord
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222111614
Abstract: (1) Background: Amyotrophic lateral sclerosis (ALS) is an incurable, neurodegenerative disease. In some cases, ALS causes behavioral disturbances and cognitive dysfunction. Swimming has revealed a neuroprotective influence on the motor neurons in ALS. (2) Methods:… read more here.
Keywords: swim training; als mice; activity; spinal cord ... See more keywords