Gray matter and white matter changes in non-demented amyotrophic lateral sclerosis patients with or without cognitive impairment: A combined voxel-based morphometry and tract-based spatial statistics whole-brain analysis
Sign Up to like & getrecommendations! Published in 2017 at "Brain Imaging and Behavior"
DOI: 10.1007/s11682-017-9722-y
Abstract: The phenotypic heterogeneity in amyotrophic lateral sclerosis (ALS) implies that patients show structural changes within but also beyond the motor cortex and corticospinal tract and furthermore outside the frontal lobes, even if frank dementia is… read more here.
Keywords: matter; tract; amyotrophic lateral; als motor ... See more keywords
Spy1, a unique cell cycle regulator, alters viability in ALS motor neurons and cell lines in response to mutant SOD1-induced DNA damage.
Sign Up to like & getrecommendations! Published in 2019 at "DNA repair"
DOI: 10.1016/j.dnarep.2018.12.005
Abstract: Increasing evidence indicates that DNA damage and p53 activation play major roles in the pathological process of motor neuron death in amyotrophic lateral sclerosis (ALS). Human SpeedyA1 (Spy1), a member of the Speedy/Ringo family, enhances… read more here.
Keywords: dna damage; response; motor neurons; als motor ... See more keywords
Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.70905
Abstract: SARM1, a protein with critical NADase activity, is a central executioner in a conserved programme of axon degeneration. We report seven rare missense or in-frame microdeletion human SARM1 variant alleles in patients with amyotrophic lateral… read more here.
Keywords: als motor; nadase; activity; sarm1 ... See more keywords