Amygdala abnormalities across disease stages in patients with sporadic amyotrophic lateral sclerosis
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DOI: 10.1002/hbm.26016
Abstract: To examine selective atrophy patterns and resting‐state functional connectivity (FC) alterations in the amygdala at different stages of amyotrophic lateral sclerosis (ALS), and to explore any correlations between amygdala abnormalities and neuropsychiatric symptoms. We used… read more here.
Keywords: amyotrophic lateral; als patients; disease stages; amygdala abnormalities ... See more keywords
Apathy and its impact on patient outcome in amyotrophic lateral sclerosis
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DOI: 10.1007/s00415-017-8688-4
Abstract: Apathy is one of the most common behavioural symptoms of amyotrophic lateral sclerosis (ALS), yet there are few studies that have investigated the relationship between apathy and quality of life (QOL) as they are experienced… read more here.
Keywords: apathy impact; amyotrophic lateral; als patients; qol ... See more keywords
Phenotypic differences of amyotrophic lateral sclerosis (ALS) in China and Germany
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DOI: 10.1007/s00415-018-8735-9
Abstract: ObjectiveThe aim of this study is to explore phenotypical differences of amyotrophic lateral sclerosis (ALS) between two cohorts from Germany and China.MethodsRegistry-based studies of ALS were conducted in South-West Germany from 2010 to 2014 and… read more here.
Keywords: amyotrophic lateral; als patients; sclerosis als; differences amyotrophic ... See more keywords
Reduced retinal nerve fiber layer (RNFL) thickness in ALS patients: a window to disease progression
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DOI: 10.1007/s00415-018-8863-2
Abstract: AbstractObjectivesTo assess RNFL thickness in ALS patients and compare it to healthy controls, and to detect possible correlations between RNFL thickness in ALS patients and disease severity and duration.MethodsStudy population consisted of ALS patients and… read more here.
Keywords: als patients; disease; rnfl thickness; thickness als ... See more keywords
Cortical progression patterns in individual ALS patients across multiple timepoints: a mosaic-based approach for clinical use
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DOI: 10.1007/s00415-020-10368-7
Abstract: Introduction The majority of imaging studies in ALS infer group-level imaging signatures from group comparisons, as opposed to estimating disease burden in individual patients. In a condition with considerable clinical heterogeneity, the characterisation of individual… read more here.
Keywords: progression patterns; cortical progression; approach; als patients ... See more keywords
Mitochondrial genome variations are associated with amyotrophic lateral sclerosis in patients from mainland China
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DOI: 10.1007/s00415-021-10659-7
Abstract: Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disorder. Mitochondrial dysfunction is involved in the complex pathophysiology of ALS; however, the role of mitochondrial DNA (mtDNA) variants in ALS is poorly understood. We aimed to… read more here.
Keywords: patients mainland; nonsynonymous variants; amyotrophic lateral; als patients ... See more keywords
Maximum Tongue Pressure is Associated with Swallowing Dysfunction in ALS Patients
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DOI: 10.1007/s00455-017-9797-z
Abstract: Maximum tongue pressure (MTP) measurement is a convenient, less invasive assessment that has been developed to quantify tongue strength; however, it is unclear whether MTP is useful for the detection of swallowing disorders in amyotrophic… read more here.
Keywords: maximum tongue; mtp; swallowing dysfunction; als patients ... See more keywords
Common genetic basis of ALS patients and soccer players may contribute to disease risk
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DOI: 10.1007/s10072-022-05990-4
Abstract: The aim of the present study was to determine the prevalence of the ACSL A/G single nucleotide polymorphism among athletes and patients with amyotrophic lateral sclerosis (ALS). ALS is a progressive neurodegenerative disorder of motor… read more here.
Keywords: risk; als patients; common genetic; fatty acid ... See more keywords
P354 The triple stimulation technique and transcranial magnetic stimulation in amyotrophic lateral sclerosis: A prospective study
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DOI: 10.1016/j.clinph.2017.07.362
Abstract: Objective The aim of the study is to evaluate the diagnostic value of triple stimulation technique (TST) and cortical excitability studies as markers of upper motor neuron degeneration in ALS patients and to compare the… read more here.
Keywords: triple stimulation; stimulation; study; als patients ... See more keywords
T42. A retrospective study of the characteristics and clinical significance of A-waves in amyotrophic lateral sclerosis
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DOI: 10.1016/j.clinph.2018.04.043
Abstract: Introduction A-wave was observed in patients with motor neuron disease (1). However, data on the characteristics and clinical significance of A-waves in patients with amyotrophic lateral sclerosis (ALS) have been scarce. Methods The F-wave studies… read more here.
Keywords: significance waves; amyotrophic lateral; characteristics clinical; als patients ... See more keywords
F127. Abnormal axonal inward rectification revealed in ALS patients with a low number of functionally intact motor units
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DOI: 10.1016/j.clinph.2018.04.290
Abstract: Introduction Amyotrophic Lateral Sclerosis (ALS) is characterized by progressive loss of motor units. Changes in axonal excitability parameters have already been shown in earlier studies differing between severely and moderately affected disease by staging the… read more here.
Keywords: motor units; axonal excitability; number; motor ... See more keywords