The Effect of SMN Gene Dosage on ALS Risk and Disease Severity
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Neurology"
DOI: 10.1002/ana.26009
Abstract: The role of the survival of motor neuron (SMN) gene in amyotrophic lateral sclerosis (ALS) is unclear, with several conflicting reports. A decisive result on this topic is needed, given that treatment options are available… read more here.
Keywords: smn gene; gene dosage; als risk; effect smn ... See more keywords
Two-step Mendelian randomization reveals a lipid-driven protective effect of type 2 diabetes on ALS
Sign Up to like & getrecommendations! Published in 2025 at "Neurological Sciences"
DOI: 10.1007/s10072-025-08407-0
Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with few therapeutic options. Observational data suggest that type 2 diabetes mellitus (T2DM) might protect against ALS, yet the mechanisms are unclear. Clarifying whether glucose or… read more here.
Keywords: als risk; effect; type diabetes; protective effect ... See more keywords
Circulating Levels of T-Cell Traits and the Risk of Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Neurobiology"
DOI: 10.1007/s12035-024-04226-0
Abstract: Amyotrophic lateral sclerosis (ALS) represents a rare and potentially fatal neurodegenerative disease. Diverse T-cell subsets could potentially exert diametrically opposite impacts upon ALS development. A two-sample Mendelian randomization (MR) analysis was performed to investigate the… read more here.
Keywords: als risk; cell subsets; cell; expression ... See more keywords
Mendelian randomization study supports relative carbohydrate intake as an independent risk factor for amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2024 at "Nutritional Neuroscience"
DOI: 10.1080/1028415x.2024.2352196
Abstract: ABSTRACT Objectives Observational studies suggested a potential correlation between dietary intake and amyotrophic lateral sclerosis (ALS), but conflicting findings exist and causality remains unclear. Here, we performed a Mendelian randomization (MR) analysis to evaluate the… read more here.
Keywords: als risk; intake; analysis; relative carbohydrate ... See more keywords
Head Injury and Amyotrophic Lateral Sclerosis: A Meta-Analysis
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DOI: 10.1159/000510987
Abstract: Background: Prior studies have suggested that head injury might be a potential risk factor of amyotrophic lateral sclerosis (ALS). However, the association has not been well established. We aimed to provide a synopsis of the… read more here.
Keywords: injury; head injury; als risk; meta analysis ... See more keywords
Pre-disease biomarkers of persistent organic pollutants (POPs) and amyotrophic lateral sclerosis (ALS) risk in Finland.
Sign Up to like & getrecommendations! Published in 2025 at "Environmental health perspectives"
DOI: 10.1289/ehp16539
Abstract: BACKGROUND Persistent organic pollutants (POPs) are toxic chemicals that bioaccumulate and were used in pesticides and industrial products/processes. POP-exposed occupations and environmental exposure to POPs have been associated with amyotrophic lateral sclerosis (ALS), but no… read more here.
Keywords: als risk; persistent organic; organic pollutants; pollutants pops ... See more keywords
Risk of Amyotrophic Lateral Sclerosis and Exposure to Particulate Matter from Vehicular Traffic: A Case-Control Study
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph18030973
Abstract: (1) Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with still unknown etiology. Some occupational and environmental risk factors have been suggested, including long-term air pollutant exposure. We carried out a pilot case-control… read more here.
Keywords: risk; pm10; exposure; study ... See more keywords