Proteomic Profiling of Unannotated Microproteins in Human Placenta Reveals XRCC6P1 as a Potential Negative Regulator of Translation.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.4c00319
Abstract: Ribosome profiling and mass spectrometry have revealed thousands of previously unannotated small and alternative open reading frames (sm/alt-ORFs) that are translated into micro/alt-proteins in mammalian cells. However, their prevalence across human tissues and biological roles… read more here.
Keywords: placenta; alt proteins; human placenta; microproteins alt ... See more keywords
Chemical labeling and proteomics for characterization of unannotated small and alternative open reading frame-encoded polypeptides.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society transactions"
DOI: 10.1042/bst20221074
Abstract: Thousands of unannotated small and alternative open reading frames (smORFs and alt-ORFs, respectively) have recently been revealed in mammalian genomes. While hundreds of mammalian smORF- and alt-ORF-encoded proteins (SEPs and alt-proteins, respectively) affect cell proliferation,… read more here.
Keywords: alt proteins; unannotated small; seps alt; alternative open ... See more keywords