Selective induction of Rab9-dependent alternative mitophagy using a synthetic derivative of isoquinoline alleviates mitochondrial dysfunction and cognitive deficits in Alzheimer's disease models
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DOI: 10.7150/thno.88718
Abstract: Rationale: Promotion of mitophagy is considered a promising strategy for the treatment of neurodegenerative diseases including Alzheimer's disease (AD). The development of mitophagy-specific inducers with low toxicity and defined molecular mechanisms is essential for the… read more here.
Keywords: alternative mitophagy; mitochondrial dysfunction; mitophagy; alt001 ... See more keywords