Outcomes After Endovascular Thrombectomy With or Without Alteplase in Routine Clinical Practice.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.1413
Abstract: Importance The effectiveness and safety of intravenous alteplase given before or concurrently with endovascular thrombectomy (EVT) is uncertain. Randomized clinical trials suggest there is little difference in outcomes but with only modest precision and insufficient… read more here.
Keywords: alteplase; endovascular thrombectomy; routine clinical; patients treated ... See more keywords
Safety and Efficacy of Dual Thrombolytic Therapy With Mutant Prourokinase and Small Bolus Alteplase for Ischemic Stroke: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2023.1262
Abstract: Importance Dual thrombolytic treatment with small bolus alteplase and mutant prourokinase has the potential to be a safer and more efficacious treatment for ischemic stroke than alteplase alone because mutant prourokinase is designed to act… read more here.
Keywords: alteplase; mutant prourokinase; group; dual thrombolytic ... See more keywords
Effect of Alteplase on Ischemic Stroke Mortality Is Dependent on Stroke Severity
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Neurology"
DOI: 10.1002/ana.26621
Abstract: Although intravenous alteplase (IV‐tPA) has a beneficial effect on functional outcome after ischemic stroke (IS), prior studies of IV‐tPA's impact on post‐stroke mortality did not have sufficient representation of more severe stroke. read more here.
Keywords: alteplase; effect; stroke mortality; stroke ... See more keywords
Tenecteplase versus alteplase for management of acute ischemic stroke: a pairwise and network meta-analysis of randomized clinical trials
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-018-1721-3
Abstract: Tenecteplase is a genetically mutated variant of alteplase with superior pharmacodynamic and pharmacokinetic properties. However, its efficacy and safety in acute ischemic strokes are limited. Hence, we conducted a study to evaluate the efficacy and… read more here.
Keywords: ischemic stroke; acute ischemic; alteplase; network meta ... See more keywords
EVALUATING THE SAFETY OF CONCURRENT INTRAVENOUS HEPARIN WITH INTRAVENOUS ALTEPLASE IN PATIENTS WITH VALVE THROMBOSIS: A CASE SERIES
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(18)32664-0
Abstract: Currently there are no clear recommendations in ACC/AHA guidelines in regards to the role or the intensity of intravenous (IV) heparin with IV alteplase during acute thrombolysis of prosthetic valves. The most recent valvular heart… read more here.
Keywords: heparin; concurrent intravenous; intravenous heparin; alteplase ... See more keywords
Effectiveness of alteplase infusion for the management of prosthetic mitral valve thrombosis in paediatric age group and proposed algorithm.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiology in the young"
DOI: 10.1017/s1047951122001652
Abstract: INTRODUCTION The incidence of prosthetic valve implantation is increasing in the paediatric population. Prosthetic valve thrombosis leading to obstruction could potentially be a life-threatening complication. There is a debate regarding optimal management of this complication,… read more here.
Keywords: alteplase; prosthetic mitral; valve; mitral valve ... See more keywords
The Use of Antiplatelet Agents and Heparin in the 24-Hour Postintravenous Alteplase Window for Neurointervention.
Sign Up to like & getrecommendations! Published in 2021 at "Neurosurgery"
DOI: 10.1093/neuros/nyaa530
Abstract: BACKGROUND Intravenous (IV) alteplase with mechanical thrombectomy has been found to be superior to alteplase alone in select patients with intracranial large vessel occlusion. Current guidelines discourage the use of antiplatelet agents or heparin for… read more here.
Keywords: alteplase; use antiplatelet; antiplatelet agents; agents heparin ... See more keywords
Efficacy and safety of intravenous thrombolysis with alteplase for treating acute ischemic stroke at different time windows
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DOI: 10.1097/md.0000000000023620
Abstract: Abstract Background: As the priority drug for treating acute ischemic stroke (AIS), alteplase is a thrombolytic drug with strong fibrin specificity. It can obviously treat AIS with high safety. However, the validity of its time… read more here.
Keywords: different time; time; alteplase; safety ... See more keywords
Alteplase associated Orolingual angioedema: A case report and literature review
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DOI: 10.1097/md.0000000000032474
Abstract: Objective: Orolingual angioedema (OA) is a rare but life-threatening complication of intravenous thrombolysis using alteplase. Angioedema can be caused by almost any medication. Administration of recombinant tissue plasminogen activator causes atypical angioedema. This study aimed… read more here.
Keywords: orolingual angioedema; alteplase; angioedema; case report ... See more keywords
Selection of Single- Versus Double-Lumen Peripherally Inserted Central Catheters and the Influence on Alteplase Use
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Infusion Nursing"
DOI: 10.1097/nan.0000000000000269
Abstract: The purpose of this article is to share the efforts of one institution in reducing risk of central line-associated bloodstream infections (CLABSIs). The aim is to review alteplase use as a marker for peripherally inserted… read more here.
Keywords: peripherally inserted; inserted central; alteplase; double lumen ... See more keywords
Effect of intravenous alteplase on ischaemic lesion water homeostasis
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Neurology"
DOI: 10.1111/ene.14088
Abstract: Intravenous (IV) lysis with alteplase is known to increase biomarkers of blood–brain barrier breakdown and has therefore been associated with secondary injuries such as hemorrhagic transformation. The impact of alteplase on brain edema formation, however,… read more here.
Keywords: lesion water; ischaemic lesion; alteplase ischaemic; water homeostasis ... See more keywords