Automated Algorithm Analysis of Sublingual Microcirculation in an International Multicentral Database Identifies Alterations Associated With Disease and Mechanism of Resuscitation
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DOI: 10.1097/ccm.0000000000004491
Abstract: Supplemental Digital Content is available in the text. Objectives: Reliable automated handheld vital microscopy image sequence analysis and the identification of disease states and effects of therapy are prerequisites for the routine use of quantitative… read more here.
Keywords: microscopy; database; sublingual microcirculation; alterations associated ... See more keywords
Impact of age on genomic alterations associated with pancreatic ductal adenocarcinoma (PDAC).
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DOI: 10.1200/jco.2017.35.4_suppl.282
Abstract: 282Background: Large scale, retrospective, sequencing projects have identified well-defined subtypes of PDAC, but therapeutic paradigms remain unchanged. We hypothesized that genomic alterations associated with PDAC in young adults (YA, age 50) to identify an enrichment… read more here.
Keywords: age genomic; genomic alterations; alterations associated; age ... See more keywords
Supplementation with a Carob (Ceratonia siliqua L.) Fruit Extract Attenuates the Cardiometabolic Alterations Associated with Metabolic Syndrome in Mice
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DOI: 10.3390/antiox9040339
Abstract: The incidence of metabolic syndrome (MetS) is increasing worldwide which makes necessary the finding of new strategies to treat and/or prevent it. The aim of this study was to analyze the possible beneficial effects of… read more here.
Keywords: fruit extract; cardiometabolic alterations; supplementation; alterations associated ... See more keywords
Myofilament Alterations Associated with Human R14del-Phospholamban Cardiomyopathy
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DOI: 10.3390/ijms24032675
Abstract: Phospholamban (PLN) is a major regulator of cardiac contractility, and human mutations in this gene give rise to inherited cardiomyopathies. The deletion of Arginine 14 is the most-prevalent cardiomyopathy-related mutation, and it has been linked… read more here.
Keywords: r14del pln; phospholamban; r14del; myofilament alterations ... See more keywords
Treatment with the Olive Secoiridoid Oleacein Protects against the Intestinal Alterations Associated with EAE
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DOI: 10.3390/ijms24054977
Abstract: Multiple sclerosis (MS) is a CNS inflammatory demyelinating disease. Recent investigations highlight the gut-brain axis as a communication network with crucial implications in neurological diseases. Thus, disrupted intestinal integrity allows the translocation of luminal molecules… read more here.
Keywords: ole protected; olive secoiridoid; treatment olive; eae ... See more keywords