FGFR2/3 genomic alterations (GA) in cell-free (cf)DNA from patients (pts) with advanced urothelial carcinoma (aUC).
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.6_suppl.565
Abstract: 565Background: Erdafitinib is approved in pts with aUC with relevant FGFR2/3 GA. BLC2001 trials in pts with activating FGFR2/3 mutations reported 40% ORR to erdafitinib (49% for those with single n... read more here.
Keywords: genomic alterations; fgfr2 genomic; dna patients; alterations cell ... See more keywords
Esophageal cancer cells resistant to T-DM1 display alterations in cell adhesion and the prostaglandin pathway
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DOI: 10.18632/oncotarget.24975
Abstract: Trastuzumab-emtansine (T-DM1) is an antibody-drug conjugate that specifically targets HER2 thanks to its antibody component trastuzumab. In spite of responses to this novel agent, acquired resistance to treatment remains a major obstacle. Prolonged in vitro… read more here.
Keywords: prostaglandin pathway; alterations cell; adhesion; cell adhesion ... See more keywords
Alterations of NK Cell Phenotype During Pregnancy in Multiple Sclerosis
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DOI: 10.3389/fimmu.2022.907994
Abstract: In multiple sclerosis (MS), relapse rate is decreased by 70-80% in the third trimester of pregnancy. However, the underlying mechanisms driving this effect are poorly understood. Evidence suggests that CD56bright NK cell frequencies increase during… read more here.
Keywords: cd56bright; alterations cell; multiple sclerosis; pregnancy ... See more keywords
PAX5 alterations in B-cell acute lymphoblastic leukemia
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DOI: 10.3389/fonc.2022.1023606
Abstract: PAX5, a master regulator of B cell development and maintenance, is one of the most common targets of genetic alterations in B-cell acute lymphoblastic leukemia (B-ALL). PAX5 alterations consist of copy number variations (whole gene,… read more here.
Keywords: pax5; leukemia; pax5 alterations; alterations cell ... See more keywords