Altered X-chromosome inactivation in T cells may promote sex-biased autoimmune diseases.
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DOI: 10.1172/jci.insight.126751
Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disorder that predominantly affects women and is driven by autoreactive T cell-mediated inflammation. It is known that individuals with multiple X-chromosomes are at increased risk for developing SLE;… read more here.
Keywords: xist rna; cells sle; altered chromosome; inactivation cells ... See more keywords