Altered expression of costimulatory molecules in dementias
Sign Up to like & getrecommendations! Published in 2021 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-021-01297-1
Abstract: Although the expression of co-stimulatory molecules plays an important role in the immune system, only little is known about their regulation in dementias. Therefore, we determined the expression of CD28, ICOS (CD278) and CTLA-4 (CD152)… read more here.
Keywords: cd8 cells; cd28 icos; cd28; ftd patients ... See more keywords
Altered expression and functional role of ion channels in leukemia: bench to bedside
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-019-02147-2
Abstract: Leukemic cells’ (LCs) survival, proliferation, activation, differentiation, and invasiveness/migration can be mediated through the function of cation and anion channels that are involved in volume regulation, polarization, cytoskeleton, and extracellular matrix reorganization. This study will… read more here.
Keywords: channels leukemia; ion channels; proliferation; ion ... See more keywords
Altered expression of inflammation-associated genes in the hypothalamus of obesity mouse models.
Sign Up to like & getrecommendations! Published in 2018 at "Nutrition research"
DOI: 10.1016/j.nutres.2018.06.006
Abstract: Metabolic inflammation is a distinct feature of obesity. Increased inflammation in the adipose tissue and the liver has been so far implicated to affect metabolic homeostasis, mainly insulin resistance. In addition to the peripherals, the… read more here.
Keywords: mouse models; inflammation; obesity; altered expression ... See more keywords
Offspring of obese mice display enhanced intake and sensitivity for palatable stimuli, with altered expression of taste signaling elements
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68216-7
Abstract: Maternal body mass index and gestational weight gain predict future obesity status of the offspring. In studies of both rodents and non-human primates, maternal obesity also predicts a preference for palatable foods in the offspring.… read more here.
Keywords: taste; obese mice; taste signaling; offspring obese ... See more keywords
Sildenafil triggers tumor lethality through altered expression of HSP90 and degradation of PKD2.
Sign Up to like & getrecommendations! Published in 2020 at "Carcinogenesis"
DOI: 10.1093/carcin/bgaa001
Abstract: The repurposing of existing drugs has emerged as an attractive additional strategy to the development of novel compounds in the fight against cancerous diseases. Inhibition of Phosphodiesterase 5 has been claimed as a potential approach… read more here.
Keywords: cancer; degradation pkd2; altered expression; expression hsp90 ... See more keywords
Association between psychiatric hospitalizations of patients with schizophrenia and polygenic risk scores based on genes with altered expression by antipsychotics
Sign Up to like & getrecommendations! Published in 2022 at "Acta Psychiatrica Scandinavica"
DOI: 10.1111/acps.13444
Abstract: To test whether a schizophrenia polygenic risk score (PRS) based on the subset of polymorphisms that affect brain expression of genes with altered expression by antipsychotics (exprAP PRS) is associated with psychiatric readmission of patients… read more here.
Keywords: schizophrenia polygenic; altered expression; polygenic risk; expression ... See more keywords
Altered expression of CYP17A1 and CYP19A1 in undescended testes of dogs with unilateral cryptorchidism.
Sign Up to like & getrecommendations! Published in 2020 at "Animal genetics"
DOI: 10.1111/age.12977
Abstract: Cryptorchidism is the most common disorder of sex development in dogs and testosterone plays a crucial role in the inguinal phase of the testes descending into the scrotum. The molecular background of impaired testosterone synthesis… read more here.
Keywords: cryptorchidism; cyp17a1 cyp19a1; altered expression; cyp17a1 ... See more keywords
The altered expression of autophagy-related genes participates in heart failure: NRBP2 and CALCOCO2 are associated with left ventricular dysfunction parameters in human dilated cardiomyopathy
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0215818
Abstract: This study aimed to analyze changes in the expression of autophagy- and phagocytosis-related genes in patients with dilated cardiomyopathy (DCM), especially in relation to left ventricular (LV) dysfunction. Furthermore, transmission electron microscopy of the diseased… read more here.
Keywords: nrbp2 calcoco2; dysfunction; expression; related genes ... See more keywords
Altered expression of Notch1 in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0224941
Abstract: Notch signaling is an evolutionarily conserved pathway that regulates cell-cell interactions through binding of Notch family receptors to their cognate ligands. Notch signaling has an essential role in vascular development and angiogenesis. Recent studies have… read more here.
Keywords: alzheimer disease; disease; expression notch1; average age ... See more keywords
A preliminary study of microRNA expression in different types of primary melanoma
Sign Up to like & getrecommendations! Published in 2019 at "Bosnian Journal of Basic Medical Sciences"
DOI: 10.17305/bjbms.2019.4271
Abstract: MicroRNAs (miRNAs) have been proven to regulate the development and progression of cancer through various mechanisms. The aim of the present study was to compare miRNA expression between primary melanomas from different sites. We analyzed… read more here.
Keywords: mir; study; primary melanoma; expression ... See more keywords
Altered Expression of Protamine-like and Their DNA Binding Induced by Cr(VI): A Possible Risk to Spermatogenesis?
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12050700
Abstract: Chromium (VI) is the most dangerous oxidation state among the stable forms of chromium. In this work, we evaluated the effect of exposing Mytilus galloprovincialis for 24 h to 1, 10, and 100 nM chromium… read more here.
Keywords: protamine like; dna; altered expression; expression ... See more keywords