How to treat histone 3 altered gliomas: molecular landscape and therapeutic developments
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DOI: 10.1080/17512433.2023.2163385
Abstract: ABSTRACT Introduction Diffuse midline gliomas (DMG) and diffuse hemispheric glioma (DHG) are both rare tumors characterized and recognized for specific alterations of histone 3 including H3K27 (DMG) and H3G34 (DHG). Despite these tumors arising from… read more here.
Keywords: treat histone; histone altered; molecular landscape; altered gliomas ... See more keywords
Challenging CDKN2A assessment in BRAF-altered gliomas: lessons from a pleomorphic xanthoastrocytoma-enriched cohort
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DOI: 10.1186/s40478-025-02089-7
Abstract: Detecting homozygous deletion (HD) of CDKN2A is critical in BRAF-altered gliomas, as this molecular alteration has both diagnostic and prognostic significance. It is predominantly associated with BRAF-altered high-grade gliomas and has been associated with poorer… read more here.
Keywords: cohort; braf; altered gliomas; braf altered ... See more keywords