Simvastatin ameliorates altered mechanotransduction in uterine leiomyoma cells.
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DOI: 10.1016/j.ajog.2020.05.012
Abstract: BACKGROUND Uterine leiomyomas, the most common tumors of the female reproductive system, feature excessive deposition of disordered stiff extracellular matrix (ECM) and fundamentally altered mechanical signaling pathways . Specifically, these alterations impact the normal dynamic… read more here.
Keywords: leiomyoma cells; altered mechanotransduction; simvastatin; mechanical signaling ... See more keywords
Involvement of the FAK Network in Pathologies Related to Altered Mechanotransduction
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DOI: 10.3390/ijms21249426
Abstract: Mechanotransduction is a physiological process in which external mechanical stimulations are perceived, interpreted, and translated by cells into biochemical signals. Mechanical stimulations exerted by extracellular matrix stiffness and cell–cell contacts are continuously applied to living… read more here.
Keywords: altered mechanotransduction; network pathologies; mechanotransduction; involvement fak ... See more keywords