A computational method using differential gene expression to predict altered metabolism of multicellular organisms.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c7mb00462a
Abstract: Altered metabolism is often identified as a cause or an effect of physiology and pathogenesis. But it is difficult to predict the metabolic flux distributions of multicellular organisms due to the lack of an explicit… read more here.
Keywords: altered metabolism; computational method; multicellular organisms; gene expression ... See more keywords
Abstract IA26: Exploiting altered metabolism as a therapeutic strategy for RAS-driven cancers
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-ia26
Abstract: We recently determined that concurrent inhibition of autophagy, using the lysosomal inhibitor chloroquine (CQ), and of ERK, using a small molecule ERK inhibitor (ERKi), synergistically suppressed the growth of pancreatic ductal adenocarcinoma (PDAC) cell lines… read more here.
Keywords: inhibition; exploiting altered; therapeutic strategy; metabolism therapeutic ... See more keywords