Alternating access mechanisms of LeuT-fold transporters: trailblazing towards the promised energy landscapes.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2016.12.006
Abstract: Secondary active transporters couple the uphill translocation of substrates to electrochemical ion gradients. Transporter conformational motion, generically referred to as alternating access, enables a central ligand binding site to change its orientation relative to the… read more here.
Keywords: energy; mechanisms leut; access mechanisms; leut fold ... See more keywords
The Alternating Access Mechanism in Mammalian Multidrug Resistance Transporters and Their Bacterial Homologs
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DOI: 10.3390/membranes13060568
Abstract: Multidrug resistance (MDR) proteins belonging to the ATP-Binding Cassette (ABC) transporter group play a crucial role in the export of cytotoxic drugs across cell membranes. These proteins are particularly fascinating due to their ability to… read more here.
Keywords: alternating access; multidrug resistance; access mechanism; mdr proteins ... See more keywords