The Pseudomonas aeruginosa effector protein TesG regulates alternative activation of macrophages through NLRC5
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DOI: 10.1128/msphere.00681-25
Abstract: ABSTRACT Pseudomonas aeruginosa is one of the most common pathogenic bacteria in the clinic. Its large genome and strong genetic plasticity enable it to survive in various environments, posing a significant threat to patient health.… read more here.
Keywords: tesg; aeruginosa; alternative activation; activation ... See more keywords
Phosphoinositide-binding protein TIPE1 promotes alternative activation of macrophages and tumor progression via PIP3/Akt/TGF-β axis.
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DOI: 10.1158/0008-5472.can-21-0003
Abstract: Macrophages perform key and distinct functions in maintaining tissue homeostasis by finely tuning their activation state. Within the tumor microenvironment, macrophages are reshaped to drive tumor progression. Here we report that tumor necrosis factor α-induced… read more here.
Keywords: tumor progression; activation; tumor; tipe1 ... See more keywords
Signaling Pathways That Mediate Alveolar Macrophage Activation by Surfactant Protein A and IL-4
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.860262
Abstract: Activation of tissue repair program in macrophages requires the integration of IL-4/IL-13 cytokines and tissue-specific signals. In the lung, surfactant protein A (SP-A) is a tissue factor that amplifies IL-4Rα-dependent alternative activation and proliferation of… read more here.
Keywords: proliferation; surfactant protein; alternative activation; signaling pathways ... See more keywords