Emerging roles of alternative cleavage and polyadenylation (APA) in human disease.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30549
Abstract: In the messenger RNA (mRNA) maturation process, the 3'-end of pre-mRNA is cleaved and a poly(A) sequence is added, this is an important determinant of mRNA stability and its cellular functions. More than 60%-70% of… read more here.
Keywords: cleavage polyadenylation; polyadenylation apa; polyadenylation; alternative cleavage ... See more keywords
Alternative cleavage and polyadenylation: key regulatory mechanisms in health and disease
Sign Up to like & getrecommendations! Published in 2025 at "RNA Biology"
DOI: 10.1080/15476286.2025.2529033
Abstract: ABSTRACT Alternative polyadenylation (APA) is a critical post-transcriptional regulatory mechanism that generates diverse mRNA isoforms by selecting different polyadenylation sites within pre-mRNAs, thereby modulating the length of the 3’ untranslated region (3’ UTR), thereby fine-tuning… read more here.
Keywords: disease; apa; alternative cleavage; regulation ... See more keywords