COVID-19 microthrombosis: unusually large VWF multimers are a platform for activation of the alternative complement pathway under cytokine storm
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Hematology"
DOI: 10.1007/s12185-022-03324-w
Abstract: ADAMTS13, a metalloproteinase, specifically cleaves unusually large multimers of von Willebrand factor (VWF), newly released from vascular endothelial cells. The ratio of ADAMTS13 activity to VWF antigen (ADAMTS13/VWF) and indicators of the alternative complement pathway… read more here.
Keywords: unusually large; activation; alternative complement; vwf ... See more keywords
Alternative complement pathway hemolytic assays reveal incomplete complement blockade in patients treated with eculizumab.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical immunology"
DOI: 10.1016/j.clim.2017.06.007
Abstract: Eculizumab is a monoclonal anti-C5 antibody used in the treatment of atypical hemolytic uremic syndrome (aHUS). We monitored complement inhibition in 16 eculizumab-treated patients suffering from HUS or transplant rejection (not aHUS patients). Blood samples… read more here.
Keywords: alternative complement; complement pathway; pathway hemolytic; blockade ... See more keywords
Alternative Complement Pathway Activation Provokes A Hypercoagulable State with Diminished Fibrinolysis.
Sign Up to like & getrecommendations! Published in 2019 at "Shock"
DOI: 10.1097/shk.0000000000001437
Abstract: INTRODUCTION Several disease processes trigger prolonged activation of the alternative complement pathway. Crosslinks between complement activation and physiologic changes in platelets and neutrophils have been identified, but how this interplay alters the hemostatic potential in… read more here.
Keywords: activation; fibrinolysis; complement pathway; alternative complement ... See more keywords
Low‐molecular weight inhibitors of the alternative complement pathway
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Reviews"
DOI: 10.1111/imr.13143
Abstract: Dysregulation of the alternative complement pathway predisposes individuals to a number of diseases. It can either be evoked by genetic alterations in or by stabilizing antibodies to important pathway components and typically leads to severe… read more here.
Keywords: alternative complement; complement pathway; molecular weight; pathway ... See more keywords
Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.712572
Abstract: The complement system is central to first-line defense against invading pathogens. However, excessive complement activation and/or the loss of complement regulation contributes to the development of autoimmune diseases, systemic inflammation, and thrombosis. One of the… read more here.
Keywords: alternative complement; factor; target; complement ... See more keywords
Alternative C3 Complement System: Lipids and Atherosclerosis
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22105122
Abstract: Familial hypercholesterolemia (FH) is increasingly associated with inflammation, a phenotype that persists despite treatment with lipid lowering therapies. The alternative C3 complement system (C3), as a key inflammatory mediator, seems to be involved in the… read more here.
Keywords: alternative complement; complement system; lipid loaded; complement ... See more keywords
Crotamine/siRNA Nanocomplexes for Functional Downregulation of Syndecan-1 in Renal Proximal Tubular Epithelial Cells
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15061576
Abstract: Proteinuria drives progressive tubulointerstitial fibrosis in native and transplanted kidneys, mainly through the activation of proximal tubular epithelial cells (PTECs). During proteinuria, PTEC syndecan-1 functions as a docking platform for properdin-mediated alternative complement activation. Non-viral… read more here.
Keywords: crotamine sirna; alternative complement; proximal tubular; epithelial cells ... See more keywords