Design and Development of Gastro-retentive Drug Delivery System for Trazodone Hydrochloride: a Promising Alternative to Innovator’s Controlled-Release Tablet
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DOI: 10.1208/s12249-022-02404-8
Abstract: Trazodone hydrochloride (TZN) is a serotonin reuptake inhibitor that treats a major depressive disorder. It exhibits a short plasma half-life of 4.1 h and shows pH-dependent solubility. Above its pKa (6.74), solubility of TZN is… read more here.
Keywords: formulation; trazodone hydrochloride; gastro retentive; tablet ... See more keywords