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   Articles with "alternative mitophagy" as a keyword



Alternative mitophagy is a major form of mitophagy in the chronically stressed heart

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recommendations! Published in 2022 at "Autophagy"

DOI: 10.1080/15548627.2022.2025573

Abstract: ABSTRACT Mitochondrial dysfunction is a key determinant of the development of cardiomyopathy in patients with obesity and diabetes. We recently reported that mitophagy is activated in the mouse heart during the chronic phase of high-fat… read more here.

Keywords: form mitophagy; alternative mitophagy; mitophagy; mitophagy major ... See more keywords

Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart.

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recommendations! Published in 2022 at "Cardiovascular research"

DOI: 10.1093/cvr/cvac003

Abstract: AIMS Well-controlled mitochondrial homeostasis, including a mitochondria-specific form of autophagy (hereafter referred to as mitophagy), is essential for maintaining cardiac function. The molecular mechanism mediating mitophagy during PO is poorly understood. We have shown previously… read more here.

Keywords: ulk1 dependent; role; alternative mitophagy; mitophagy ... See more keywords

Distinct Roles of DRP1 in Conventional and Alternative Mitophagy in Obesity Cardiomyopathy.

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recommendations! Published in 2023 at "Circulation research"

DOI: 10.1161/circresaha.123.322512

Abstract: RATIONALE Obesity induces cardiomyopathy characterized by hypertrophy and diastolic dysfunction. Whereas mitophagy mediated through an Atg7-dependent mechanism serves as an essential mechanism to maintain mitochondrial quality during the initial development of obesity cardiomyopathy, Rab9-dependent alternative… read more here.

Keywords: hfd consumption; alternative mitophagy; obesity cardiomyopathy; mitophagy ... See more keywords

The Role of Alternative Mitophagy in Heart Disease

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24076362

Abstract: Autophagy is essential for maintaining cellular homeostasis through bulk degradation of subcellular constituents, including misfolded proteins and dysfunctional organelles. It is generally governed by the proteins Atg5 and Atg7, which are critical regulators of the… read more here.

Keywords: role alternative; alternative mitophagy; heart; mitophagy heart ... See more keywords

Selective induction of Rab9-dependent alternative mitophagy using a synthetic derivative of isoquinoline alleviates mitochondrial dysfunction and cognitive deficits in Alzheimer's disease models

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recommendations! Published in 2024 at "Theranostics"

DOI: 10.7150/thno.88718

Abstract: Rationale: Promotion of mitophagy is considered a promising strategy for the treatment of neurodegenerative diseases including Alzheimer's disease (AD). The development of mitophagy-specific inducers with low toxicity and defined molecular mechanisms is essential for the… read more here.

Keywords: alternative mitophagy; mitochondrial dysfunction; mitophagy; alt001 ... See more keywords