AAPM Task Group 298: Recommendations on certificate program/alternative pathway candidate education and training
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.13777
Abstract: Abstract Entry into the field of clinical medical physics is most commonly accomplished through the completion of a Commission on Accreditation of Medical Physics Educational Programs (CAMPEP)‐accredited graduate and residency program. To allow a mechanism… read more here.
Keywords: physics; alternative pathway; education training; medical physics ... See more keywords
Initial properdin binding contributes to alternative pathway activation at the surface of viable and necrotic cells
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149259
Abstract: Properdin, the only known positive regulator of the complement system, stabilizes the C3 convertase, thereby increasing its half‐life. In contrast to most other complement factors, properdin is mainly produced extrahepatically by myeloid cells. Recent data… read more here.
Keywords: properdin binding; alternative pathway; necrotic cells; properdin ... See more keywords
IL‐1/IL‐1R signaling induced by all‐trans‐retinal contributes to complement alternative pathway activation in retinal pigment epithelium
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30103
Abstract: The underlying mechanisms of complement activation in Stargardt disease type 1 (STGD1) and age‐related macular degeneration (AMD) are not fully understood. Overaccumulation of all‐trans‐retinal (atRAL) has been proposed as the pathogenic factor in both diseases.… read more here.
Keywords: complement alternative; alternative pathway; rpe cells; activation ... See more keywords
Detection of C3 Nephritic Factor by Hemolytic Assay.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1016-9_15
Abstract: C3 nephritic Factor (C3NeF) is autoantibody that binds neoepitopes of the C3 convertase C3bBb, resulting in a stabilization of the enzyme. First functional characterizations of C3NeF were performed by hemolytic assays using preactivated sheep erythrocytes… read more here.
Keywords: alternative pathway; detection nephritic; sheep erythrocytes; nephritic factor ... See more keywords
The role of the alternative pathway in paroxysmal nocturnal hemoglobinuria and emerging treatments
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2022.2109462
Abstract: ABSTRACT Introduction Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by uncontrolled activation of the terminal complement pathway, leading to intravascular hemolysis (IVH) and a prothrombotic state. Treatment with terminal complement (C5) inhibitors, the current standard of… read more here.
Keywords: complement; alternative pathway; nocturnal hemoglobinuria; emerging treatments ... See more keywords
Genetic analysis of the complement pathway in C3 glomerulopathy
Sign Up to like & getrecommendations! Published in 2018 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfy033
Abstract: Background C3 glomerulopathy often presents with a membranoproliferative glomerulonephritis (MPGN) pattern, and is principally caused by unrestricted activation of the complement alternative pathway. Genetic abnormalities of the complement system critically implicate in the pathogenesis of… read more here.
Keywords: analysis complement; complement pathway; alternative pathway; complement ... See more keywords
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Reviews"
DOI: 10.1111/imr.13129
Abstract: Structures of alternative pathway proteins have offered a comprehensive structural basis for understanding the molecular mechanisms governing activation and regulation of the amplification pathway of the complement cascade. Although properdin (FP) is required in vivo… read more here.
Keywords: structural studies; studies offer; offer framework; alternative pathway ... See more keywords
Genetic variability shapes the alternative pathway complement activity and predisposition to complement‐related diseases
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Reviews"
DOI: 10.1111/imr.13131
Abstract: The implementation of next‐generation sequencing technologies has provided a sharp picture of the genetic variability in the components and regulators of the alternative pathway (AP) of the complement system and has revealed the association of… read more here.
Keywords: genetic variability; pathway complement; alternative pathway; complement ... See more keywords
Alternative pathway activation: Ever ancient and ever new
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DOI: 10.1111/imr.13132
Abstract: Primitive underpinnings of the alternative pathway (AP), namely, a C3‐like protein, likely arose more than a billion years ago. The development of an AP amplification loop, while greatly enhancing speed and potency, also presents a… read more here.
Keywords: ever ancient; ancient ever; alternative pathway; activation ever ... See more keywords
Gene targeting as a therapeutic avenue in diseases mediated by the complement alternative pathway
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DOI: 10.1111/imr.13149
Abstract: The complement alternative pathway (AP) is implicated in numerous diseases affecting many organs, ranging from the rare hematological disease paroxysmal nocturnal hemoglobinuria (PNH), to the common blinding disease age‐related macular degeneration (AMD). Critically, the AP… read more here.
Keywords: targeting therapeutic; alternative pathway; gene targeting; complement alternative ... See more keywords
The complement alternative pathway and hemostasis
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DOI: 10.1111/imr.13150
Abstract: The complement and hemostatic systems are complex systems, and both involve enzymatic cascades, regulators, and cell components—platelets, endothelial cells, and immune cells. The two systems are ancestrally related and are defense mechanisms that limit infection… read more here.
Keywords: alternative pathway; complement; pathway hemostasis; complement alternative ... See more keywords