Aberrant Ki‐67 expression through 3′UTR alternative polyadenylation in breast cancers
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12364
Abstract: Ki‐67 (MKI67) is a marker of cellular proliferation of cancer. Here, we show that Ki‐67 is post‐transcriptionally regulated through alternative polyadenylation (APA) and microRNAs in breast cancer. We show that shortening of the Ki‐67 3′UTR… read more here.
Keywords: breast; aberrant expression; utr alternative; polyadenylation ... See more keywords
Discovery of alternative polyadenylation dynamics from single cell types
Sign Up to like & getrecommendations! Published in 2020 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2020.04.009
Abstract: Alternative polyadenylation (APA) occurs in the process of mRNA maturation by adding a poly(A) tail at different locations, resulting increased diversity of mRNA isoforms and contributing to the complexity of gene regulatory network. Benefit from… read more here.
Keywords: single cell; cell types; discovery alternative; cell ... See more keywords
2007 – DIFFERENTIAL ALTERNATIVE POLYADENYLATION LANDSCAPES MEDIATE HEMATOPOIETIC STEM CELL ACTIVATION AND REGULATE GLUTAMINE METABOLISM
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.169
Abstract: Alternative polyadenylation (APA) is emerging as an important regulatory mechanism of RNA and protein isoform expression by controlling 3’-untranslated region (3’-UTR) composition. The relevance of APA in stem cell hierarchies in vivo remains elusive. Using… read more here.
Keywords: stem cell; glutamine metabolism; alternative polyadenylation; cell ... See more keywords
Alternative polyadenylation expands the mRNA isoform repertoire of human CD46.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2017.05.004
Abstract: Alternative polyadenylation is a prevalent mechanism regulating mammalian gene expression. While tandem 3'-Untranslated-Region (3'UTR) polyadenylation changes expression levels, Intronic PolyAdenylation generates shorter transcripts encoding truncated proteins. Intronic PolyAdenylation regulates 20% of genes and is especially… read more here.
Keywords: intronic polyadenylation; human cd46; polyadenylation; cd46 ... See more keywords
Transcriptome 3′end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07580-5
Abstract: Diversification at the transcriptome 3′end is an important and evolutionarily conserved layer of gene regulation associated with differentiation and dedifferentiation processes. Here, we identify extensive transcriptome 3′end-alterations in neuroblastoma, a tumour entity with a paucity of… read more here.
Keywords: end; apa; differentiation; transcriptome end ... See more keywords
Comprehensive Characterization of Alternative Polyadenylation in Human Cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the National Cancer Institute"
DOI: 10.1093/jnci/djx223
Abstract: Background Alternative polyadenylation (APA) is emerging as a major post-transcriptional mechanism for gene regulation, and dysregulation of APA contributes to several human diseases. However, the functional consequences of APA in human cancer are not fully… read more here.
Keywords: human cancer; apa events; cancer cell; cancer ... See more keywords
CRISPR-iPAS: a novel dCAS13-based method for alternative polyadenylation interference
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac108
Abstract: Abstract Alternative polyadenylation (APA) plays an important role in gene regulation. With the recent application of novel sequencing technology in APA profiling, an ever-increasing number of APA genes/sites have been identified. However, the phenotypic relevance… read more here.
Keywords: alternative polyadenylation; dcas13; apa; interference ... See more keywords
CFIm-mediated alternative polyadenylation remodels cellular signaling and miRNA biogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac114
Abstract: Abstract The mammalian cleavage factor I (CFIm) has been implicated in alternative polyadenylation (APA) in a broad range of contexts, from cancers to learning deficits and parasite infections. To determine how the CFIm expression levels… read more here.
Keywords: cfim; alternative polyadenylation; mediated alternative; cfim mediated ... See more keywords
Crosstalk between alternative polyadenylation and miRNAs in the regulation of protein translational efficiency.
Sign Up to like & getrecommendations! Published in 2018 at "Genome research"
DOI: 10.1101/gr.231506.117
Abstract: 3' UTRs play important roles in the gene regulation network via their influence on mRNA stability, translational efficiency, and subcellular localization. For a given gene, 3' UTRs of different lengths generated by alternative polyadenylation (APA)… read more here.
Keywords: translational efficiency; regulation protein; mirnas regulation; alternative polyadenylation ... See more keywords
Noncanonical Alternative Polyadenylation Contributes to Gene Regulation in Response to Hypoxia[OPEN]
Sign Up to like & getrecommendations! Published in 2017 at "Plant Cell"
DOI: 10.1105/tpc.16.00746
Abstract: Stress affects the production and fate of alternative mRNA isoforms to coordinate and fine-tune the adaptation of plants to the environment. Stresses from various environmental challenges continually confront plants, and their responses are important for… read more here.
Keywords: response; mrna isoforms; hypoxia; alternative polyadenylation ... See more keywords
The three as: Alternative splicing, alternative polyadenylation and their impact on apoptosis in immune function.
Sign Up to like & getrecommendations! Published in 2021 at "Immunological reviews"
DOI: 10.1111/imr.13018
Abstract: The latest advances in next-generation sequencing studies and transcriptomic profiling over the past decade have highlighted a surprising frequency of genes regulated by RNA processing mechanisms in the immune system. In particular, two control steps… read more here.
Keywords: apoptosis; splicing alternative; three alternative; alternative splicing ... See more keywords