Farnesyltransferase-Mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras.
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DOI: 10.1021/acschembio.7b00374
Abstract: Mutationally activated Ras is one of the most common oncogenic drivers found across all malignancies, and its selective inhibition has long been a goal in both pharma and academia. One of the oldest and most… read more here.
Keywords: mediated delivery; alternative prenylation; covalent inhibitor; farnesyltransferase mediated ... See more keywords