Assembly of alternative prothrombinase by extracellular histones initiate and disseminate intravascular coagulation.
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DOI: 10.1182/blood.2019002973
Abstract: Thrombin generation is pivotal to both physiological blood clot formation and pathological development of disseminated intravascular coagulation (DIC). In critical illness, extensive cell damage can release histones into the circulation, which can increase thrombin generation… read more here.
Keywords: coagulation; alternative prothrombinase; prothrombinase; extracellular histones ... See more keywords