Alternative Sigma Factor of Staphylococcus aureus Interacts with the Cognate Antisigma Factor Primarily Using Its Domain 3.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00881
Abstract: σB, an alternative sigma factor, is usually employed to tackle the general stress response in Staphylococcus aureus and other Gram-positive bacteria. This protein, involved in S. aureus-mediated pathogenesis, is typically blocked by RsbW, an antisigma… read more here.
Keywords: alternative sigma; staphylococcus aureus; factor; sigma factor ... See more keywords
Targeting the alternative sigma factor RpoN to combat virulence in Pseudomonas aeruginosa
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DOI: 10.1038/s41598-017-12667-y
Abstract: Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that infects immunocompromised and cystic fibrosis patients. Treatment is difficult due to antibiotic resistance, and new antimicrobials are needed to treat infections. The alternative sigma factor 54 (σ54,… read more here.
Keywords: alternative sigma; factor rpon; pseudomonas aeruginosa; virulence ... See more keywords
Interactions between DksA and Stress-Responsive Alternative Sigma Factors Control Inorganic Polyphosphate Accumulation in Escherichia coli
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DOI: 10.1128/jb.00133-20
Abstract: Inorganic polyphosphate (polyP) is an evolutionarily ancient, widely conserved biopolymer required for stress resistance and pathogenesis in diverse bacteria, but we do not understand how its synthesis is regulated. In this work, I gained new… read more here.
Keywords: sigma factors; inorganic polyphosphate; polyp; stress ... See more keywords
The Alternative Sigma Factor SigL Influences Clostridioides difficile Toxin Production, Sporulation, and Cell Surface Properties
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.871152
Abstract: The alternative sigma factor SigL (Sigma-54) facilitates bacterial adaptation to the extracellular environment by modulating the expression of defined gene subsets. A homolog of the gene encoding SigL is conserved in the diarrheagenic pathogen Clostridioides… read more here.
Keywords: sigl; cell surface; alternative sigma; factor ... See more keywords