NQO1 regulates expression and alternative splicing of apoptotic genes associated with Alzheimer's disease in PC12 cells
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2917
Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and cognitive dysfunction. Quinone oxidoreductase 1 (NQO1) is an antioxidant enzyme that plays an important role in controlling cellular redox state, whose expression… read more here.
Keywords: nqo1 regulates; disease; alzheimer disease; regulates expression ... See more keywords
Profiles of prognostic alternative splicing signature in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.2875
Abstract: Previous studies have demonstrated the role of abnormal alternative splicing (AS) in tumor progression. This study examines the prognostic index (PI) of alternative splices (ASs) in patients with hepatocellular carcinoma (HCC). The clinical features and… read more here.
Keywords: hepatocellular carcinoma; analysis; patients hcc; cox regression ... See more keywords
COL3A1: Potential prognostic predictor for head and neck cancer based on immune‐microenvironment alternative splicing
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5170
Abstract: We aimed to identify a novel prognostic biomarker for head and neck squamous cell carcinoma (HNSCC) based on tumor immunology‐related alternative splicing (AS). Data for 502 HNSCC and 44 normal samples were obtained from the… read more here.
Keywords: head neck; prognostic predictor; expression; alternative splicing ... See more keywords
Prognostic risk assessment model for alternative splicing events and splicing factors in malignant pleural mesothelioma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5174
Abstract: Malignant pleural mesothelioma (MPM) is a rare and highly malignant thoracic tumor. Although alternative splicing (AS) is associated with tumor prognosis, the prognostic significance of AS in MPM is unknown. read more here.
Keywords: malignant pleural; pleural mesothelioma; alternative splicing; prognostic risk ... See more keywords
LncRNA BCLET variant confers bladder cancer susceptibility through alternative splicing of MSANTD2 exon 1.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6072
Abstract: BACKGROUND Alternative splicing (AS)-related single nucleotide polymorphisms (SNPs) are associated with risk of cancers, but the potential mechanism has not been fully elucidated. METHODS Two-stage case-control studies comprising 1630 cases and 2504 controls were conducted… read more here.
Keywords: bclet; alternative splicing; msantd2; bladder cancer ... See more keywords
RNPS1 functions as an oncogenic splicing factor in cervical cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2686
Abstract: Numerous recent studies suggest that cancer‐specific splicing alteration is a critical contributor to the pathogenesis of cancer. RNA‐binding protein with serine‐rich domain 1, RNPS1, is an essential regulator of the splicing process. However, the defined… read more here.
Keywords: cervical cancer; rnps1; cancer; cell ... See more keywords
Global interpretation of novel alternative splicing events in human congenital pulmonary airway malformations: A pilot study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30216
Abstract: Little is known about differentially expressed genes (DEGs) and alternative splicing (AS) landscapes in congenital lung malformations (CLMs). We applied reference‐based assembly of sequencing reads from RNA sequencing (RNA‐seq) libraries to identify DEGs and AS… read more here.
Keywords: pulmonary airway; cpam; expression; alternative splicing ... See more keywords
RNA splicing alteration in the response to platinum chemotherapy in ovarian cancer: A possible biomarker and therapeutic target
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Research Reviews"
DOI: 10.1002/med.21741
Abstract: Since its discovery, alternative splicing has been recognized as a powerful way for a cell to amplify the genetic information and for a living organism to adapt, evolve, and survive. We now know that a… read more here.
Keywords: chemotherapy; platinum; response; ovarian cancer ... See more keywords
An overview of cdc2‐like kinase 1 (Clk1) inhibitors and their therapeutic indications
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DOI: 10.1002/med.21928
Abstract: Over the past decade, Clk1 has been identified as a promising target for the treatment of various diseases, in which deregulated alternative splicing plays a role. First small molecules targeting Clk1 are in clinical trials… read more here.
Keywords: like kinase; overview cdc2; clk1; alternative splicing ... See more keywords
Mutually exclusive alternative splicing of pre‐mRNAs
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DOI: 10.1002/wrna.1468
Abstract: Pre‐mRNA alternative splicing is an important mechanism used to expand protein diversity in higher eukaryotes, and mutually exclusive splicing is a specific type of alternative splicing in which only one of the exons in a… read more here.
Keywords: exclusive alternative; splicing pre; exclusive splicing; mutually exclusive ... See more keywords
Microexon alternative splicing of small GTPase regulators: Implication in central nervous system diseases
Sign Up to like & getrecommendations! Published in 2021 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1678
Abstract: Microexons are small sized (≤51 bp) exons which undergo extensive alternative splicing in neurons, microglia, embryonic stem cells, and cancer cells, giving rise to cell type specific protein isoforms. Due to their small sizes, microexons provide… read more here.
Keywords: microexon alternative; gtpase; central nervous; alternative splicing ... See more keywords