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   Articles with "alternative splicing" as a keyword



Nuclear Condensates of WW Domain‐Containing Adaptor With Coiled‐Coil Regulate Mitophagy via Alternative Splicing

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202406759

Abstract: Biomolecular condensates segregate nuclei into discrete regions, facilitating the execution of distinct biological functions. Here, it is identified that the WW domain containing adaptor with coiled‐coil (WAC) is localized to nuclear speckles via its WW… read more here.

Keywords: coil; alternative splicing; coiled coil; domain containing ... See more keywords

Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure‐Based Virtual Screening

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202416323

Abstract: Pancreatic cancer is an aggressive malignancy with a poor prognosis and limited treatment options. Cdc‐like kinase 4 (CLK4), a kinase that regulates alternative splicing by phosphorylating spliceosome components, is implicated in aberrant splicing events driving… read more here.

Keywords: cancer; novel clk4; alternative splicing; pancreatic cancer ... See more keywords

NQO1 regulates expression and alternative splicing of apoptotic genes associated with Alzheimer's disease in PC12 cells

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recommendations! Published in 2023 at "Brain and Behavior"

DOI: 10.1002/brb3.2917

Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and cognitive dysfunction. Quinone oxidoreductase 1 (NQO1) is an antioxidant enzyme that plays an important role in controlling cellular redox state, whose expression… read more here.

Keywords: nqo1 regulates; disease; alzheimer disease; regulates expression ... See more keywords

Profiles of prognostic alternative splicing signature in hepatocellular carcinoma

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recommendations! Published in 2020 at "Cancer Medicine"

DOI: 10.1002/cam4.2875

Abstract: Previous studies have demonstrated the role of abnormal alternative splicing (AS) in tumor progression. This study examines the prognostic index (PI) of alternative splices (ASs) in patients with hepatocellular carcinoma (HCC). The clinical features and… read more here.

Keywords: hepatocellular carcinoma; analysis; patients hcc; cox regression ... See more keywords

COL3A1: Potential prognostic predictor for head and neck cancer based on immune‐microenvironment alternative splicing

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recommendations! Published in 2022 at "Cancer Medicine"

DOI: 10.1002/cam4.5170

Abstract: We aimed to identify a novel prognostic biomarker for head and neck squamous cell carcinoma (HNSCC) based on tumor immunology‐related alternative splicing (AS). Data for 502 HNSCC and 44 normal samples were obtained from the… read more here.

Keywords: head neck; prognostic predictor; expression; alternative splicing ... See more keywords

Prognostic risk assessment model for alternative splicing events and splicing factors in malignant pleural mesothelioma

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recommendations! Published in 2022 at "Cancer Medicine"

DOI: 10.1002/cam4.5174

Abstract: Malignant pleural mesothelioma (MPM) is a rare and highly malignant thoracic tumor. Although alternative splicing (AS) is associated with tumor prognosis, the prognostic significance of AS in MPM is unknown. read more here.

Keywords: malignant pleural; pleural mesothelioma; alternative splicing; prognostic risk ... See more keywords

LncRNA BCLET variant confers bladder cancer susceptibility through alternative splicing of MSANTD2 exon 1.

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recommendations! Published in 2023 at "Cancer medicine"

DOI: 10.1002/cam4.6072

Abstract: BACKGROUND Alternative splicing (AS)-related single nucleotide polymorphisms (SNPs) are associated with risk of cancers, but the potential mechanism has not been fully elucidated. METHODS Two-stage case-control studies comprising 1630 cases and 2504 controls were conducted… read more here.

Keywords: bclet; alternative splicing; msantd2; bladder cancer ... See more keywords

RNPS1 functions as an oncogenic splicing factor in cervical cancer cells

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recommendations! Published in 2022 at "IUBMB Life"

DOI: 10.1002/iub.2686

Abstract: Numerous recent studies suggest that cancer‐specific splicing alteration is a critical contributor to the pathogenesis of cancer. RNA‐binding protein with serine‐rich domain 1, RNPS1, is an essential regulator of the splicing process. However, the defined… read more here.

Keywords: cervical cancer; rnps1; cancer; cell ... See more keywords

Alternative splicing generates a novel ferroportin isoform with a shorter C‐terminal and an intact iron‐ and hepcidin‐binding property

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recommendations! Published in 2024 at "IUBMB Life"

DOI: 10.1002/iub.2809

Abstract: Ferroportin (FPN) is a transmembrane protein and is the only known iron exporter that helps in maintaining iron homeostasis in vertebrates. To maintain stable iron equilibrium in the body, ferroportin works in conjunction with a… read more here.

Keywords: alternative splicing; iron; novel isoform; hepcidin ... See more keywords

Global interpretation of novel alternative splicing events in human congenital pulmonary airway malformations: A pilot study

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recommendations! Published in 2022 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.30216

Abstract: Little is known about differentially expressed genes (DEGs) and alternative splicing (AS) landscapes in congenital lung malformations (CLMs). We applied reference‐based assembly of sequencing reads from RNA sequencing (RNA‐seq) libraries to identify DEGs and AS… read more here.

Keywords: pulmonary airway; cpam; expression; alternative splicing ... See more keywords

Alternative Splicing of SORBS1 Affects Neuromuscular Junction Integrity in Myotonic Dystrophy Type 1

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recommendations! Published in 2025 at "Journal of Cachexia, Sarcopenia and Muscle"

DOI: 10.1002/jcsm.70112

Abstract: Myotonic dystrophy type 1 (DM1) is a multisystemic neuromuscular disorder characterized by CTG repeat expansion in the 3′ untranslated region of the dystrophia myotonica protein kinase coding gene. The presence of expanded CTG repeats in… read more here.

Keywords: splicing sorbs1; dystrophy type; alternative splicing; myotonic dystrophy ... See more keywords