Methionyl-tRNA formyltransferase utilizes 10-formyldihydrofolate as an alternative substrate and impacts antifolate drug action
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DOI: 10.1099/mic.0.001297
Abstract: Methionyl-tRNA formyltransferase (Fmt)-mediated formylation of Met-tRNAfMet to fMet-tRNAfMet is crucial for efficient initiation of translation in bacteria and the eukaryotic organelles. Folate dehydrogenase-cyclohydrolase (FolD), a bifunctional enzyme, carries out conversion of 5,10-methylene tetrahydrofolate (5,10-CH2-THF) to… read more here.
Keywords: thf; alternative substrate; methionyl trna; trna formyltransferase ... See more keywords
Alternative Substrate Metabolism in Yarrowia lipolytica
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DOI: 10.3389/fmicb.2018.01077
Abstract: Recent advances in genetic engineering capabilities have enabled the development of oleochemical producing strains of Yarrowia lipolytica. Much of the metabolic engineering effort has focused on pathway engineering of the product using glucose as the… read more here.
Keywords: engineering; utilization; metabolism; alternative substrate ... See more keywords