Articles with "alternative synthesis" as a keyword



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An alternative synthesis of the lipophilic tail portion of abediterol using linear-selective hydroformylation

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Published in 2019 at "Tetrahedron Letters"

DOI: 10.1016/j.tetlet.2019.01.037

Abstract: Abstract Abediterol is a compound currently in development for the treatment of respiratory disease at AstraZeneca. In this work we employ hydroformylation, an under-utilised reaction in the synthesis of pharmaceutical intermediates, as a key step… read more here.

Keywords: synthesis lipophilic; hydroformylation; synthesis; abediterol ... See more keywords
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An Alternative Synthesis of Bipyrenol: A High-Yield Oxidative Coupling Reaction of a Pyrene Derivative with Cu(BF4)2·nH2O

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Published in 2017 at "Synthesis"

DOI: 10.1055/s-0036-1588819

Abstract: An alternative synthesis has been developed with the objective of extending the applications of bipyrenol in mind. The key reaction involves the oxidative coupling of 2-hydroxypyrene menthyl carbonate to afford the corresponding pyrene dimer. In… read more here.

Keywords: alternative synthesis; synthesis bipyrenol; reaction; oxidative coupling ... See more keywords
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An Alternative Synthesis of 2,6-Dimethoxyl-1,4-Benzoquinone

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Published in 2017 at "Journal of Chemical Research"

DOI: 10.3184/174751917x14894997017379

Abstract: An economic four-step synthesis of 2,6-dimethoxy-1,4-benzoquinone was achieved in 68% overall yield starting from aniline. The reaction sequence involved conversion to 1,3,5-tribromoaniline, deamination, methoxylation, and oxidation. The procedure is operationally simple and amenable to scale-up… read more here.

Keywords: alternative synthesis; synthesis dimethoxyl; benzoquinone; synthesis ... See more keywords