Alternative translation initiation from two in-frame start codons in DHX33 gene.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.201
Abstract: DHX33 has been shown to play key roles in promoting cell proliferation. We have previously found that DHX33 protein is a doublet. In this report, we discovered that DHX33 doublet is due to alternative translation… read more here.
Keywords: initiation two; initiation; alternative translation; translation ... See more keywords
Alternative Translation Initiation Generates a Functionally Distinct Isoform of the Stress-Activated Protein Kinase MK2.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.05.024
Abstract: Alternative translation is an important mechanism of post-transcriptional gene regulation leading to the expression of different protein isoforms originating from the same mRNA. Here, we describe an abundant long isoform of the stress/p38MAPK-activated protein kinase… read more here.
Keywords: isoform stress; isoform; activated protein; alternative translation ... See more keywords
The meiotic regulator JASON utilizes alternative translation initiation sites to produce differentially localized forms
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/erx222
Abstract: Leaky ribosome scanning produces a long Golgi-localized and a short plasma membrane-localized version of the JAS protein, with the short version required during meiosis to ensure products are reduced. read more here.
Keywords: utilizes alternative; regulator jason; jason utilizes; alternative translation ... See more keywords
Mammalian alternative translation initiation is mostly nonadaptive.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology and evolution"
DOI: 10.1093/molbev/msaa063
Abstract: Alternative translation initiation (ATLI) refers to the existence of multiple translation initiation sites per gene and is a widespread phenomenon in eukaryotes. ATLI is commonly assumed to be advantageous through creating proteome diversity or regulating… read more here.
Keywords: initiation mostly; initiation; mammalian alternative; alternative translation ... See more keywords
To New Beginnings: Riboproteogenomics Discovery of N-Terminal Proteoforms in Arabidopsis Thaliana
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.778804
Abstract: Alternative translation initiation is a widespread event in biology that can shape multiple protein forms or proteoforms from a single gene. However, the respective contribution of alternative translation to protein complexity remains largely enigmatic. By… read more here.
Keywords: terminal proteoforms; alternative translation; arabidopsis thaliana; translation initiation ... See more keywords
The PERK Branch of the Unfolded Protein Response Promotes DLL4 Expression by Activating an Alternative Translation Mechanism
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11020142
Abstract: Delta-like 4 (DLL4) is a pivotal endothelium specific Notch ligand that has been shown to function as a regulating factor during physiological and pathological angiogenesis. DLL4 functions as a negative regulator of angiogenic branching and… read more here.
Keywords: dll4 expression; stress; expression; translation ... See more keywords