Identification and functional comparison of novel alternatively spliced isoforms of human YAP.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13618
Abstract: As a key effector of the Hippo pathway, yes‐associated protein (YAP) is a major regulator of cell proliferation and apoptosis. In this study, 23 hYAP isoforms were identified in HEK293 cells, with 14 isoforms being… read more here.
Keywords: identification functional; alternatively spliced; novel alternatively; hyap isoforms ... See more keywords
Characterization of overexpression of the alternatively spliced isoform of the protein phosphatase 2A catalytic subunit in cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.10.093
Abstract: PP2Acα2 is a recently discovered PP2Acα alternative splicing isoform that can be induced following serum withdrawal. It shows enhanced binding to immunoglobulin binding protein 1 and is overexpressed in chronic lymphocytic leukemia patients. Current knowledge… read more here.
Keywords: protein; characterization overexpression; overexpression; alternatively spliced ... See more keywords
Isoform-specific functions of an evolutionarily conserved 3 bp micro-exon alternatively spliced from another exon in Drosophila homothorax gene
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-69644-1
Abstract: Micro-exons are exons of very small size (usually 3–30 nts). Some micro-exons are alternatively spliced. Their functions, regulation and evolution are largely unknown. Here, we present an example of an alternatively spliced 3 bp micro-exon… read more here.
Keywords: micro ex8; exon; alternatively spliced; micro exon ... See more keywords
TMOD-30. CHARACTERIZATION OF AN ALTERNATIVELY SPLICED NTRK2 VARIANT IN GLIOMAS
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.1129
Abstract: Recent work has uncovered oncogenic TRK fusions in a wide range of cancer types, including adult and pediatric gliomas. With some exceptions, many of these fusions tend to occur at very low frequencies below 1–2%,… read more here.
Keywords: gliomas; characterization alternatively; alternatively spliced; tmod characterization ... See more keywords
Characterization of alternatively spliced transcript variants of glycophorin A and glycophorin B genes in Chinese blood donors.
Sign Up to like & getrecommendations! Published in 2022 at "Vox sanguinis"
DOI: 10.1111/vox.13252
Abstract: BACKGROUND AND OBJECTIVES The molecular basis of MNS blood group variants is not fully clear yet. In this study, we have characterized mRNA variants of GYPA and GYPB genes to reveal whether alternative RNA splicing… read more here.
Keywords: gypa gypb; alternatively spliced; characterization alternatively; blood donors ... See more keywords
Characterization and Structure of Alternatively Spliced Transcript Variant of Human Intestinal Alkaline Phosphatase (ALPI) Gene.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of nutritional science and vitaminology"
DOI: 10.3177/jnsv.68.284
Abstract: Intestinal-type alkaline phosphatase (IAP) is expressed at a high concentration in the brush border membrane of intestinal epithelial cells and is known to be a gut mucosal defense factor. In humans, a single gene (ALPI)… read more here.
Keywords: alternatively spliced; alpi gene; alkaline phosphatase; gene ... See more keywords
Alternative splicing signature of alveolar type II epithelial cells of Tibetan pigs under hypoxia-induced
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2022.984703
Abstract: Alternative splicing (AS) allows the generation of multiple transcript variants from a single gene and affects biological processes by generating protein diversity in organisms. In total, 41,642 AS events corresponding to 9,924 genes were identified,… read more here.
Keywords: type epithelial; alternatively spliced; alternative splicing; alveolar type ... See more keywords
Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers
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DOI: 10.3390/cancers13020348
Abstract: Simple Summary Pyruvate kinase muscle type (PKM) is a key enzyme in glycolysis and is a mediator of the Warburg effect in tumors. The association of PKM with survival of cancer patients is controversial. In… read more here.
Keywords: spliced pkm; human cancers; pkm transcripts; alternatively spliced ... See more keywords
An Alternatively Spliced Variant of METTL3 Mediates Tumor Suppression in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13040669
Abstract: Many post-transcriptional mRNA processing steps play crucial roles in tumorigenesis and the progression of cancers, such as N6-methyladenosine (m6A) modification and alternative splicing. Upregulation of methyltransferase-like 3 (METTL3), the catalytic core of the m6A methyltransferase… read more here.
Keywords: alternatively spliced; mettl3; hepatocellular carcinoma; splice variants ... See more keywords
Sequence and Evolutionary Features for the Alternatively Spliced Exons of Eukaryotic Genes
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20153834
Abstract: Alternative splicing of pre-mRNAs is a crucial mechanism for maintaining protein diversity in eukaryotes without requiring a considerable increase of genes in the number. Due to rapid advances in high-throughput sequencing technologies and computational algorithms,… read more here.
Keywords: spliced exons; evolutionary features; alternatively spliced; sequence evolutionary ... See more keywords
Alternatively Spliced Isoforms of the P2X7 Receptor: Structure, Function and Disease Associations
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158174
Abstract: The P2X7 receptor (P2X7R) is an ATP-gated membrane ion channel that is expressed by multiple cell types. Following activation by extracellular ATP, the P2X7R mediates a broad range of cellular responses including cytokine and chemokine… read more here.
Keywords: structure function; alternatively spliced; function; p2x7 receptor ... See more keywords