A journey between high altitude hypoxia and critical patient hypoxia: What can it teach us about compression and the management of critical disease?
Sign Up to like & getrecommendations! Published in 2018 at "Medicina Intensiva"
DOI: 10.1016/j.medine.2018.05.013
Abstract: Abstract High altitude sickness (hypobaric hypoxia) is a form of cellular hypoxia similar to that suffered by critically ill patients. The study of mountaineers exposed to extreme hypoxia offers the advantage of involving a relatively… read more here.
Keywords: disease; journey high; altitude hypoxia; altitude ... See more keywords
High-altitude hypoxia exacerbates dextran sulfate sodium (DSS)-induced colitis by upregulating Th1 and Th17 lymphocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1975017
Abstract: High altitude hypoxia (HAH) involves the pathogenesis of ulcerative colitis (UC) and gastrointestinal erosions. However, the mechanism of effects of HAH in colitis remains controversial. This study reports the immunomodulation mediated by HAH to enhancing… read more here.
Keywords: high altitude; colitis; mice; altitude hypoxia ... See more keywords
High‐altitude hypoxia‐induced rat alveolar cell injury by increasing autophagy
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Experimental Pathology"
DOI: 10.1111/iep.12434
Abstract: Autophagy has been implicated in the pathogenesis of various lung diseases. This study aimed to investigate the role of autophagy in lung injury induced by high‐altitude hypoxia. Wistar rats were randomized into four groups for… read more here.
Keywords: altitude hypoxia; treatment; high altitude; injury ... See more keywords
Ethiopian Native Highlander's Adaptation to Chronic High-Altitude Hypoxia
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/5749382
Abstract: People living in a high-altitude environment have distinct lifelong challenges. Adaptive mechanisms have allowed high-altitude residents to survive in a low-oxygen environment for thousands of years. The purpose of this review was to provide a… read more here.
Keywords: adaptation; altitude; altitude hypoxia; high altitude ... See more keywords
Effect of High-altitude Hypoxia Environment on Uric Acid Excretion, Desmin Protein Level in Podocytes, and Na+-K+- ATPase Activity.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2022.68.6.14
Abstract: To investigate the oxidative stress and adaptive compensation of kidneys in rats in high-altitude hypoxia environments, 20 Wistar rats (3 months) were randomly and equally grouped. The rats in the test group were fed in… read more here.
Keywords: altitude hypoxia; test group; group; high altitude ... See more keywords
The Influences and Mechanisms of High-altitude Hypoxia Exposure on Drug Metabolism.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug metabolism"
DOI: 10.2174/1389200224666221228115526
Abstract: BACKGROUND The special environment of high-altitude hypoxia not only changes the physiological state of the body but also affects the metabolic process of many drugs, which may affect the safety and efficacy of these drugs.… read more here.
Keywords: altitude hypoxia; metabolism; drug metabolism; high altitude ... See more keywords
Physiology and Transcriptomics Analysis Reveal the Contribution of Lungs on High-Altitude Hypoxia Adaptation in Tibetan Sheep
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.885444
Abstract: The Tibetan sheep is an indigenous species on the Tibetan plateau with excellent adaptability to high-altitude hypoxia and is distributed at altitudes of 2500–5000 m. The high-altitude hypoxia adaptation of Tibetan sheep requires adaptive reshaping… read more here.
Keywords: altitude hypoxia; adaptation; physiology; high altitude ... See more keywords
Resveratrol Ameliorates High Altitude Hypoxia-Induced Osteoporosis by Suppressing the ROS/HIF Signaling Pathway
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DOI: 10.3390/molecules27175538
Abstract: Hypoxia at high-altitude leads to osteoporosis. Resveratrol (RES), as an antioxidant, has been reported to promote osteoblastogenesis and suppress osteoclastogenesis. However, the therapeutic effect of RES against osteoporosis induced by high-altitude hypoxia remains unclear. Thus,… read more here.
Keywords: altitude hypoxia; hypoxia induced; osteoporosis; hypoxia ... See more keywords
High-altitude Hypoxia Influences the Activities of the Drug-Metabolizing Enzyme CYP3A1 and the Pharmacokinetics of Four Cardiovascular System Drugs
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DOI: 10.3390/ph15101303
Abstract: (1) Background: High-altitude hypoxia has been shown to affect the pharmacokinetic properties of drugs. Although there is a high incidence of cardiovascular disease among individuals living in high-altitude areas, studies on the effect of high-altitude… read more here.
Keywords: altitude hypoxia; metabolizing enzyme; drug metabolizing; high altitude ... See more keywords