Aspherical, Nanostructured Microparticles for Targeted Gene Delivery to Alveolar Macrophages
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DOI: 10.1002/adhm.201700478
Abstract: Introducing novel shapes to particulate carrier systems adds unique features to modern drug and gene delivery. Depending on the route of administration, particle geometry can influence deposition and fate within biological environments. In this work,… read more here.
Keywords: alveolar macrophages; aspherical nanostructured; delivery; nanostructured microparticles ... See more keywords
Anti‐inflammatory effect of octyl gallate in alveolar macrophages cells and mice with acute lung injury
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29536
Abstract: Acute lung injury (ALI) is an inflammatory process, and has high incidence and mortality. ALI and the acute respiratory distress syndrome are two common complications worldwide that result in acute lung failure, sepsis, and death.… read more here.
Keywords: anti inflammatory; alveolar macrophages; acute lung; lung injury ... See more keywords
IFNγ receptor down‐regulation facilitates Legionella survival in alveolar macrophages
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4ma1019-152r
Abstract: Legionella pneumophila is an opportunistic human pathogen and causative agent of the acute pneumonia known as Legionnaire's disease. Upon inhalation, the bacteria replicate in alveolar macrophages (AM), within an intracellular vacuole termed the Legionella‐containing vacuole.… read more here.
Keywords: ifngr1 regulation; pneumophila; regulation; alveolar macrophages ... See more keywords
FBXO6 regulates the antiviral immune responses via mediating alveolar macrophages survival
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28203
Abstract: Inducing early apoptosis in alveolar macrophages is one of the strategies influenza A virus (IAV) evolved to subvert host immunity. Correspondingly, the host mitochondrial protein nucleotide‐binding oligomerization domain‐like receptor (NLR)X1 is reported to interact with… read more here.
Keywords: regulates antiviral; immune responses; degradation nlrx1; fbxo6 regulates ... See more keywords
Alveolar Macrophages in Allergic Asthma: the Forgotten Cell Awakes
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DOI: 10.1007/s11882-017-0681-6
Abstract: Purpose of ReviewThe role of alveolar macrophages in innate immune responses has long been appreciated. Here, we review recent studies evaluating the participation of these cells in allergic inflammation.Recent FindingsImmediately after allergen exposure, monocytes are… read more here.
Keywords: asthma forgotten; alveolar macrophages; forgotten cell; inflammation ... See more keywords
SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages
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DOI: 10.1016/j.celrep.2020.02.112
Abstract: SUMMARY Acute lung injury (ALI) is a lethal inflammatory lung disorder whose incidence is on the rise. Alveolar macrophages normally act to resolve inflammation, but when dysregulated they can provoke ALI. We demonstrate that monocyte-derived… read more here.
Keywords: inflammatory function; alveolar macrophages; cd11b macrophages; function alveolar ... See more keywords
The modulatory effects of the PDE4 inhibitors CHF6001 and roflumilast in alveolar macrophages and lung tissue from COPD patients.
Sign Up to like & getrecommendations! Published in 2019 at "Cytokine"
DOI: 10.1016/j.cyto.2019.154739
Abstract: BACKGROUND We compared the anti-inflammatory effects of phosphodiesterase type 4 (PDE4) inhibitor roflumilast with CHF6001, a novel PDE4 inhibitor designed for inhaled administration, using human alveolar macrophages (AM) and lung tissue explants models. METHODS AM… read more here.
Keywords: macrophages lung; tissue; lung tissue; copd patients ... See more keywords
The effect of BCG vaccination on alveolar macrophages obtained from induced sputum from healthy volunteers.
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DOI: 10.1016/j.cyto.2020.155135
Abstract: The anti-tuberculosis vaccine Bacillus Calmette-Guérin (BCG) is able to boost innate immune responses through a process called 'trained immunity'. It is hypothesized that BCG-induced trained immunity contributes to protection against Mycobacterium tuberculosis infection. Since alveolar… read more here.
Keywords: vaccination alveolar; alveolar macrophages; bcg vaccination; induced sputum ... See more keywords
Anti-inflammatory effects of adiponectin in cigarette smoke-activated alveolar macrophage through the COX-2/PGE2 and TLRs signaling pathway.
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DOI: 10.1016/j.cyto.2020.155148
Abstract: OBJECTIVES Airway macrophages represents a central site for the mechanisms involved in the complex interactions between environmental triggers and airway inflammation. Based on anti-inflammatory activity of adiponectin, we hypothesize that adiponectin inhibits the proinflammatory cytokines… read more here.
Keywords: anti inflammatory; cigarette smoke; adiponectin; alveolar macrophages ... See more keywords
Paraquat promotes acute lung injury in rats by regulating alveolar macrophage polarization through glycolysis.
Sign Up to like & getrecommendations! Published in 2021 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2021.112571
Abstract: The present study investigates whether paraquat (PQ) regulates polarization of alveolar macrophages through glycolysis and promotes the occurrence of acute lung injury in rats. In vivo, the PQ intraperitoneal injection was used to construct a… read more here.
Keywords: alveolar macrophages; glycolysis; polarization; macrophage ... See more keywords
Atorvastatin protected from paraquat-induced cytotoxicity in alveolar macrophages via down-regulation of TLR-4.
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DOI: 10.1016/j.etap.2016.11.011
Abstract: The current study designed to clarify the mechanism of paraquat-induced cytotoxicity and protective effects of Atorvastatin on freshly isolated alveolar macrophages (AMs). AMs were collected via bronchoalveolar lavage and exposed to various concentrations of paraquat… read more here.
Keywords: alveolar macrophages; paraquat; tlr; induced cytotoxicity ... See more keywords