Isolation and Characterization of Human Alveolar Type II Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8570-8_7
Abstract: Alveolar type II (ATII) cells synthesize, store, and secrete pulmonary surfactant and restore the epithelium after damage to the alveolar epithelium. Isolation of human ATII cells provides a valuable tool to study their function under… read more here.
Keywords: isolation characterization; characterization human; human alveolar; alveolar type ... See more keywords
Stem Cells in Lungs.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-31206-0_13
Abstract: The respiratory system plays an essential role for human life. This system (like all others) undergoes physiological regeneration due to many types of stem cells found both in the respiratory tract itself and in the… read more here.
Keywords: medicine; alveolar type; lung stem; stem ... See more keywords
MicroRNA-34a Suppresses Autophagy in Alveolar Type II Epithelial Cells in Acute Lung Injury by Inhibiting FoxO3 Expression
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation"
DOI: 10.1007/s10753-017-0537-1
Abstract: Excessive autophagic activity of alveolar type II epithelial (AT-II) cells is one of the main causes of acute lung injury (ALI); however, the underlying molecular mechanism remains to be determined. The microRNAs (miRNAs) are involved… read more here.
Keywords: alveolar type; mir 34a; expression; autophagic activity ... See more keywords
TGF beta inhibits expression of SP-A, SP-B, SP-C, but not SP-D in human alveolar type II cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.003
Abstract: TGF beta is a multifunctional cytokine that regulates alveolar epithelial cells as well as immune cells and fibroblasts. TGF beta inhibits surfactant protein A, B and C expression in fetal human lung and can inhibit… read more here.
Keywords: alveolar type; beta; beta inhibits; type cells ... See more keywords
Differentiation of immortalized human multi-lineage progenitor to alveolar type 2-like cells: angiotensin-converting enzyme 2 expression and binding of severe acute respiratory syndrome coronavirus 2 spike and spike 1 proteins
Sign Up to like & getrecommendations! Published in 2021 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2021.07.017
Abstract: Along with the nasal epithelium, the lung epithelium is a portal of entry for sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and many other respiratory viruses. In the case of SARS-CoV-2, the virus surface spike… read more here.
Keywords: spike proteins; alveolar type; like cells; spike ... See more keywords
Irx1 regulates dental outer enamel epithelial and lung alveolar type II epithelial differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Developmental biology"
DOI: 10.1016/j.ydbio.2017.07.011
Abstract: The Iroquois genes (Irx) appear to regulate fundamental processes that lead to cell proliferation, differentiation, and maturation during development. In this report, the Iroquois homeobox 1 (Irx1) transcription factor was functionally disrupted using a LacZ… read more here.
Keywords: alveolar type; outer enamel; differentiation; irx1 ... See more keywords
Gene therapeutics for surfactant dysfunction disorders: Targeting the alveolar type 2 epithelial cell.
Sign Up to like & getrecommendations! Published in 2022 at "Human gene therapy"
DOI: 10.1089/hum.2022.130
Abstract: Genetic disorders of surfactant dysfunction result in significant morbidity and mortality, among infants, children, and adults. Available medical interventions are limited, non-specific and generally ineffective. As such, the need for effective therapies remains. Pathogenic variants… read more here.
Keywords: alveolar type; gene; surfactant dysfunction; gene therapeutics ... See more keywords
Organoid-based expansion of patient-derived primary alveolar type 2 cells for establishment of alveolus epithelial Lung-Chip cultures
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Physiology - Lung Cellular and Molecular Physiology"
DOI: 10.1152/ajplung.00153.2021
Abstract: Development of effective treatment strategies for lung tissue destruction as seen in emphysema would greatly benefit from representative human in vitro models of the alveolar compartment. Studying how cellular cross talk and/or (altered) biomechanical cues… read more here.
Keywords: primary alveolar; physiology; alveolar type; patient derived ... See more keywords
Dexmedetomidine Attenuates LPS-Stimulated Alveolar Type II Cells' Injury through Upregulation of miR-140-3p and Partial Suppression of PD-L1 Involving Inactivating JNK-Bnip3 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Canadian Respiratory Journal"
DOI: 10.1155/2022/8433960
Abstract: Dexmedetomidine (DEX), which is reported to be a newly discovered, novel α-2 adrenoceptor agonist, is known to exhibit anti-inflammatory properties in several diseases. DEX regulates inflammation-related signaling pathways and genes through interactions with several miRNAs.… read more here.
Keywords: mir 140; jnk bnip3; expression; dex ... See more keywords
The Kinome of Human Alveolar Type II and Basal Cells, and its Reprogramming in Lung Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2018-0283oc
Abstract: The discovery of mutant tyrosine kinases as oncogenic drivers of lung adenocarcinomas has changed our basic understanding of the development and therapy of lung cancer. Yet, we have an incomplete understanding of the expressed kinases… read more here.
Keywords: basal cells; lung cancer; lung; alveolar type ... See more keywords
Improving Mitochondrial Function in Viral Infection: Targeting Cellular Metabolism
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2022-0096ed
Abstract: Host-mediated immunopathology is a common feature of respiratory viral pathogens, including influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For this reason, targeting of immune dysregulation that mediates lung injury is an attractive proposition… read more here.
Keywords: choline; cdp choline; infection; alveolar type ... See more keywords