Preservation of ALYREF Phase Separation Mitigates Doxorubicin‐Induced Cardiomyocyte DNA Damage and Cardiotoxicity
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DOI: 10.1002/advs.202505270
Abstract: The clinical utility of the anticancer agent doxorubicin (DOX) is limited by its dose‐dependent cardiotoxicity. ALYREF, a nuclear protein that preserves genomic stability through interactions with intranuclear components or as an m⁵C‐binding regulator of mRNA… read more here.
Keywords: dna damage; alyref; phase separation; cardiotoxicity ... See more keywords
Identification of ALYREF in pan cancer as a novel cancer prognostic biomarker and potential regulatory mechanism in gastric cancer
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DOI: 10.1038/s41598-024-56895-5
Abstract: ALYREF is considered as a specific mRNA m5C-binding protein which recognizes m5C sites in RNA and facilitates the export of RNA from the nucleus to the cytoplasm. Expressed in various tissues and highly involved in… read more here.
Keywords: cancer; analysis; alyref; cell ... See more keywords