Association of Genetic Variants Linked to Late-Onset Alzheimer Disease With Cognitive Test Performance by Midlife
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.5491
Abstract: Key Points Question At what age do individuals with higher genetic risk of Alzheimer disease first show cognitive differences from individuals with lower genetic risk, and which of 32 cognitive measures show the earliest difference?… read more here.
Keywords: alzheimer; alzheimer disease; higher genetic; genetic risk ... See more keywords
Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.443
Abstract: The hippocampus has been the target of stem cell transplantations in preclinical studies focused on Alzheimer's disease, with results showing improvements in histological and behavioral outcomes. The corpus callosum is another structure that is affected… read more here.
Keywords: alzheimer; stem cell; corpus callosum; neural stem ... See more keywords
Silica Nanodepletors: Targeting and Clearing Alzheimer's β‐Amyloid Plaques
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201910475
Abstract: Abnormal accumulation of β‐amyloid (Aβ) peptide aggregates in the brain is a major hallmark of Alzheimer's disease (AD). Aβ aggregates interfere with neuronal communications, ultimately causing neuronal damage and brain atrophy. Much effort has been… read more here.
Keywords: amyloid; silica nanodepletors; clearing alzheimer; targeting clearing ... See more keywords
APOE2 Exacerbates TDP‐43 Related Toxicity in the Absence of Alzheimer Pathology
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26580
Abstract: Recent evidence supports a link between increased TDP‐43 burden and the presence of an APOE4 gene allele in Alzheimer's disease (AD); however, it is difficult to conclude the direct effect of APOE on TDP‐43 pathology… read more here.
Keywords: exacerbates tdp; absence; pathology; tdp related ... See more keywords
Sleep Disturbance and Alzheimer's Disease: The Glial Connection.
Sign Up to like & getrecommendations! Published in 2022 at "Neurochemical research"
DOI: 10.1007/s11064-022-03578-0
Abstract: Poor quality and quantity of sleep are very common in elderly people throughout the world. Growing evidence has suggested that sleep disturbances could accelerate the process of neurodegeneration. Recent reports have shown a positive correlation… read more here.
Keywords: disturbance alzheimer; alzheimer; sleep disturbance; alzheimer disease ... See more keywords
Study on Lentivirus-Mediated ABCA7 Improves Neurocognitive Function and Related Mechanisms in the C57BL/6 Mouse Model of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-0889-x
Abstract: ATP-binding cassette transporter A7 (ABCA7) is expressed in the hippocampus and cortex of the brain and was confirmed to be involved in the development of Alzheimer’s disease (AD). Previous studies have demonstrated that ABCA7 regulated… read more here.
Keywords: alzheimer disease; study; alzheimer; abca7 overexpression ... See more keywords
Computational analysis of Alzheimer-causing mutations in amyloid precursor protein and presenilin 1.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.108168
Abstract: Single-point mutations in the genes coding for amyloid precursor protein (APP) and presenilin 1 (PS1), the active subunit of γ-secretase that cleaves APP to produce Aβ, are the main causes of rare but severe familial… read more here.
Keywords: protein; precursor protein; alzheimer; amyloid precursor ... See more keywords
Can healthy lifestyle reduce disease progression of Alzheimer’s during a global pandemic of COVID-19?
Sign Up to like & getrecommendations! Published in 2021 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2021.101406
Abstract: The novel coronavirus disease 2019 (COVID-19) has pushed the medical system to its breaking point. While the virus does not discriminate, the elderly and those with comorbidities, including hypertension severe obesity, diabetes mellitus, coronary disease,… read more here.
Keywords: healthy lifestyle; lifestyle reduce; disease; alzheimer ... See more keywords
Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer’s dementia subjects
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.07.020
Abstract: Recent reports describing lymphatic vasculature in the meninges have challenged the traditional understanding of interstitial solute clearance from the central nervous system, although the significance of this finding in human neurological disease remains unclear. To… read more here.
Keywords: vasculature; alzheimer; lymphatic vasculature; vasculature human ... See more keywords
New classes of carbazoles as potential multi-functional anti-Alzheimer's agents.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103164
Abstract: Multi-Target approach is particularly promising way to drug discovery against Alzheimer's disease. In the present study, we synthesized a series of compounds comprising the carbazole backbone linked to the benzyl piperazine, benzyl piperidine, pyridine, quinoline,… read more here.
Keywords: alzheimer; multi functional; compound; classes carbazoles ... See more keywords
Novel carbazole-stilbene hybrids as multifunctional anti-Alzheimer agents.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103977
Abstract: Molecules capable of engaging with multiple targets associated with pathological condition of Alzheimer's disease have proved to be potential anti-Alzheimer's agents. In our goal to develop multitarget-directed ligands for the treatment of Alzheimer's disease, a… read more here.
Keywords: novel carbazole; carbazole stilbene; anti alzheimer; alzheimer ... See more keywords