An Approach to Apply BDNF Targeting Fe3O4-Based Nanoparticles as Multifunctional Anti-Alzheimer Agents.
Sign Up to like & getrecommendations! Published in 2024 at "Small"
DOI: 10.1002/smll.202403625
Abstract: To search for novel anti-Alzheimer agents, multifunctional Fe3O4-based nanoparticles (FSSIO) is designed and prepared which contain ferulic acid (FA) and Simvastatin linked to the surface of Fe3O4 particles. In vitro tests confirmed that FSSIO possessed… read more here.
Keywords: anti alzheimer; based nanoparticles; alzheimer agents; fe3o4 based ... See more keywords
Potential of flavonoids as anti-Alzheimer’s agents: bench to bedside
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-021-18165-z
Abstract: Developing therapies for neurodegenerative diseases are challenging because of the presence of blood–brain barrier and Alzheimer being one of the commonest and uprising neurodegenerative disorders possess the need for developing novel therapies. Alzheimer’s is attributed… read more here.
Keywords: anti alzheimer; agents bench; bench bedside; flavonoids anti ... See more keywords
Synthesis and biological evaluation of flavone-8-acrylamide derivatives as potential multi-target-directed anti Alzheimer agents and investigation of binding mechanism with acetylcholinesterase.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.102960
Abstract: In a search for novel multifunctional anti-Alzheimer agents, a congeneric set of seventeen flavone-8-acrylamide derivatives (8a─q) were synthesized and evaluated for their cholinesterase inhibitory, antioxidant, neuroprotective and modulation of Aβ aggregation activities. The target compounds… read more here.
Keywords: acrylamide derivatives; alzheimer agents; flavone acrylamide; anti alzheimer ... See more keywords
Novel carbazole-stilbene hybrids as multifunctional anti-Alzheimer agents.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103977
Abstract: Molecules capable of engaging with multiple targets associated with pathological condition of Alzheimer's disease have proved to be potential anti-Alzheimer's agents. In our goal to develop multitarget-directed ligands for the treatment of Alzheimer's disease, a… read more here.
Keywords: novel carbazole; carbazole stilbene; anti alzheimer; alzheimer ... See more keywords
Donepezil-Inspired Multitargeting Indanone Derivatives as Effective Anti-Alzheimer's Agents.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00535
Abstract: In continuous efforts to develop anti-Alzheimer's agents, we rationally designed and synthesized a series of multitargeting molecules by incorporating the essential molecular features of the standard drug donepezil. Among the series, compound 4b showed multitargeting… read more here.
Keywords: anti alzheimer; donepezil inspired; compound; alzheimer agents ... See more keywords
Design, synthesis, biological evaluation and molecular docking study of novel pyridoxine–triazoles as anti-Alzheimer's agents
Sign Up to like & getrecommendations! Published in 2020 at "RSC Advances"
DOI: 10.1039/d0ra04942e
Abstract: A series of multi-target natural product-pyridoxine based derivatives were designed, synthesized, characterized and evaluated as anti-Alzheimer agents. In vitro testing revealed the multi-functional properties of compounds such as inhibition of acetylcholinesterase (AChE), antioxidant and metal… read more here.
Keywords: pyridoxine; design synthesis; ache; anti alzheimer ... See more keywords
Insights on therapeutic approaches of natural anti-Alzheimer's agents in the management of Alzheimer's disease: A future perspective
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Alzheimer's Disease"
DOI: 10.1177/13872877241296557
Abstract: In the current scenario, Alzheimer's disease is a complex, challenging, and arduous health issue, and its prevalence, together with comorbidities, is accelerating around the universe. Alzheimer's disease is becoming a primary concern that significantly impacts… read more here.
Keywords: anti alzheimer; alzheimer disease; disease; alzheimer ... See more keywords
Natural Products as Potential anti-Alzheimer Agents.
Sign Up to like & getrecommendations! Published in 2019 at "Current medicinal chemistry"
DOI: 10.2174/0929867326666190618113613
Abstract: Medicinal plants have curative properties due to the presence of various complex chemical substances of different composition, which are found as secondary metabolites in one or more parts of the plant. The diverse secondary metabolites… read more here.
Keywords: alzheimer agents; natural products; potential anti; alzheimer ... See more keywords
Molecular scaffold and biological activities of anti- Alzheimer agents
Sign Up to like & getrecommendations! Published in 2022 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v22i2.30
Abstract: Alzheimer’s disease (AD) is an age-associated and neurodegenerative illness which results in progressive dementia and severe cognitive malfunctions. The pathogenesis of AD is affected by some factors such as accumulation of β-amyloid, aggregation of tau… read more here.
Keywords: alzheimer agents; molecular scaffold; anti alzheimer; activities anti ... See more keywords