Alzheimer-like pathology in the parietal cortex and hippocampus of aged donkeys
Sign Up to like & getrecommendations! Published in 2022 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2022.01.007
Abstract: Neurodegenerative disorders are gaining ever more importance in ageing populations of animals and people. Altered insulin signaling and type II diabetes have been linked to the development of Alzheimer's disease (AD) in humans and AD-like… read more here.
Keywords: hippocampus aged; pathology parietal; alzheimer like; pathology ... See more keywords
Improved cognitive impairments by silencing DMP1 via enhancing the proliferation of neural progenitor cell in Alzheimer‐like mice
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13601
Abstract: Alzheimer's disease (AD) is age‐related progressive neurological dysfunction. Limited clinical benefits for current treatments indicate an urgent need for novel therapeutic strategies. Previous transcriptomic analysis showed that DMP1 expression level was increased in AD model… read more here.
Keywords: cell; progenitor cell; neural progenitor; like mice ... See more keywords
Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Translational Neurodegeneration"
DOI: 10.1186/s40035-018-0133-9
Abstract: BackgroundDown syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles. Our laboratory recently demonstrated the disturbance of PI3K/AKT/mTOR… read more here.
Keywords: alzheimer like; mtor signalling; mtor; syndrome ... See more keywords
Neurotrophic Treatment Initiated During Early Postnatal Development Prevents the Alzheimer-Like Behavior and Synaptic Dysfunction
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Alzheimer's Disease"
DOI: 10.3233/jad-201599
Abstract: Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by impairments in synaptic plasticity and cognitive performance. Cognitive dysfunction and loss of neuronal plasticity are known to begin decades before the clinical diagnosis of… read more here.
Keywords: development; treatment; dysfunction; alzheimer like ... See more keywords