Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2019.05.007
Abstract: Amyloid-β (Aβ) and α-synuclein (αS) are two intrinsically disordered proteins (IDPs) at the centers of the pathogenesis of Alzheimer's and Parkinson's diseases, respectively. Different hypotheses have been proposed for explanation of the molecular mechanisms of… read more here.
Keywords: intrinsically disordered; biology; parkinson diseases; disordered proteins ... See more keywords
Shared perturbations in the metallome and metabolome of Alzheimer’s, Parkinson’s, Huntington’s, and dementia with Lewy bodies: A systematic review
Sign Up to like & getrecommendations! Published in 2020 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2020.101152
Abstract: Despite differences in presentation, age-related dementing diseases such as Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases (HD), and dementia with Lewy bodies (DLB) may share pathogenic processes. This review aims to systematically assemble and compare… read more here.
Keywords: lewy bodies; dementia lewy; alzheimer parkinson; shared perturbations ... See more keywords
Multimodal retinal imaging to detect and understand Alzheimer’s and Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2021.07.007
Abstract: Retinal neurodegeneration and visual dysfunctions have been reported in a majority of Alzheimer's and Parkinson's patients, and, in light of the quest for novel biomarkers for these neurodegenerative proteinopathies, the retina has been receiving increasing… read more here.
Keywords: alzheimer parkinson; multimodal retinal; parkinson; parkinson disease ... See more keywords
Combustion and friction-derived nanoparticles and industrial-sourced nanoparticles: The culprit of Alzheimer and Parkinson's diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental research"
DOI: 10.1016/j.envres.2019.108574
Abstract: Redox-active, strongly magnetic, combustion and friction-derived nanoparticles (CFDNPs) are abundant in particulate matter air pollution. Urban children and young adults with Alzheimer disease Continuum have higher numbers of brain CFDNPs versus clean air controls. CFDNPs… read more here.
Keywords: combustion friction; parkinson diseases; derived nanoparticles; alzheimer parkinson ... See more keywords
Possible role of endocannabinoids in olfactory and taste dysfunctions in Alzheimer’s and Parkinson’s patients and volumetric changes in the brain
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2022.03.047
Abstract: The purpose of this study is to determine the volumes of primary brain regions associated with smell and taste in Alzheimer's and Parkinson's patients and healthy controls using MR imaging and examine volumetric changes in… read more here.
Keywords: volumetric changes; alzheimer parkinson; parkinson patients; taste ... See more keywords
miRNAs Identify Shared Pathways in Alzheimer's and Parkinson's Diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2019.05.006
Abstract: Despite the identification of several dozens of common genetic variants associated with Alzheimer's disease (AD) and Parkinson's disease (PD), most of the genetic risk remains uncharacterised. Therefore, it is important to understand the role of… read more here.
Keywords: pathways alzheimer; parkinson; identify shared; shared pathways ... See more keywords
Neuroprotective Effects of Lactoferrin in Alzheimer's and Parkinson's Diseases: A Narrative Review.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00679
Abstract: Recent advancements in lactoferrin research have uncovered that lactoferrin does function not only as an antimicrobial protein but also as an immunomodulatory, anticancer, and neuroprotective agent. Focusing on neuroprotection, this literature review delineates how lactoferrin… read more here.
Keywords: alzheimer parkinson; review; neuroprotective effects; parkinson diseases ... See more keywords
Investigations on 16-Arylideno Steroids as a New Class of Neuroprotective Agents for the Treatment of Alzheimer's and Parkinson's Diseases.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.6b00313
Abstract: Neuroinflammatory mechanisms mediated by activated glial and cytokines (TNF-α, IL-1β) might contribute to neuronal degeneration leading to Alzheimer's (AD) and Parkinson's disease (PD). Lipopolysaccharide (LPS) is an inflammogen derived from the cell wall of Gram-negative… read more here.
Keywords: steroidal derivatives; treatment; investigations arylideno; alzheimer parkinson ... See more keywords
Lamina-specific immunohistochemical signatures in the olfactory bulb of healthy, Alzheimer’s and Parkinson’s disease patients
Sign Up to like & getrecommendations! Published in 2022 at "Communications Biology"
DOI: 10.1038/s42003-022-03032-5
Abstract: Traditional neuroanatomy immunohistology studies involve low-content analyses of a few antibodies of interest, typically applied and compared across sequential tissue sections. The efficiency, consistency, and ultimate insights of these studies can be substantially improved using… read more here.
Keywords: bulb; disease patients; parkinson disease; olfactory bulb ... See more keywords
The prion-like propagation hypothesis in Alzheimer's and Parkinson's disease
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Neurology"
DOI: 10.1097/wco.0000000000000672
Abstract: Purpose of review This study, taking the example of Alzheimer's and Parkinson's diseases, presents the experimental and human data that support the hypothesis that A&bgr;, tau, and &agr;-synuclein may seed and propagate the pathology and… read more here.
Keywords: pathology; alzheimer; alzheimer parkinson; disease ... See more keywords
Extracellular vesicles in the study of Alzheimer's and Parkinson's diseases: Methodologies applied from cells to biofluids
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15697
Abstract: Extracellular vesicles (EVs) are gaining increased importance in fundamental research as key players in disease pathogenic mechanisms, but also in translational and clinical research due to their value in biomarker discovery, either for diagnostics and/or… read more here.
Keywords: evs isolation; extracellular vesicles; alzheimer parkinson; parkinson diseases ... See more keywords